Detalles de la búsqueda
1.
Discovery of novel serine palmitoyltransferase inhibitors as cancer therapeutic agents.
Bioorg Med Chem
; 26(9): 2452-2465, 2018 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29669694
2.
A novel PET probe to selectively image heat shock protein 90α/ß isoforms in the brain.
EJNMMI Radiopharm Chem
; 9(1): 19, 2024 Mar 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-38436869
3.
Anti-angiogenic and anti-tumor effects of TAK-593, a potent and selective inhibitor of vascular endothelial growth factor and platelet-derived growth factor receptor tyrosine kinase.
Cancer Sci
; 104(4): 486-94, 2013 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-23305239
4.
Design, synthesis, and evaluation of novel VEGFR2 kinase inhibitors: discovery of [1,2,4]triazolo[1,5-a]pyridine derivatives with slow dissociation kinetics.
Bioorg Med Chem
; 21(15): 4714-29, 2013 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23755884
5.
Structure-based design, synthesis, and evaluation of imidazo[1,2-b]pyridazine and imidazo[1,2-a]pyridine derivatives as novel dual c-Met and VEGFR2 kinase inhibitors.
Bioorg Med Chem
; 21(24): 7686-98, 2013 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24216091
6.
Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor.
Bioorg Med Chem
; 21(8): 2333-2345, 2013 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23498918
7.
A novel pyrrolo[3, 2-d]pyrimidine derivative, as a vascular endothelial growth factor receptor and platelet-derived growth factor receptor tyrosine kinase inhibitor, shows potent antitumor activity by suppression of tumor angiogenesis.
Cancer Sci
; 103(5): 939-44, 2012 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-22320850
8.
Design, synthesis, and evaluation of imidazo[1,2-b]pyridazine derivatives having a benzamide unit as novel VEGFR2 kinase inhibitors.
Bioorg Med Chem
; 20(24): 7051-8, 2012 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23123015
9.
Biochemical characterization of TAK-593, a novel VEGFR/PDGFR inhibitor with a two-step slow binding mechanism.
Biochemistry
; 50(5): 738-51, 2011 Feb 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-21182308
10.
Biochemical characterization of a novel type-II VEGFR2 kinase inhibitor: comparison of binding to non-phosphorylated and phosphorylated VEGFR2.
Bioorg Med Chem
; 19(18): 5342-51, 2011 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21885287
11.
N-phenyl-N'-[4-(5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as novel inhibitors of VEGFR and FGFR kinases.
Bioorg Med Chem
; 18(20): 7150-63, 2010 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20833551
12.
Design, synthesis, and evaluation of 5-methyl-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidine derivatives: novel VEGFR2 kinase inhibitors binding to inactive kinase conformation.
Bioorg Med Chem
; 18(20): 7260-73, 2010 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20833055
13.
New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase.
ACS Med Chem Lett
; 11(8): 1645-1652, 2020 Aug 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-34345355
14.
Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase.
J Med Chem
; 63(6): 3215-3226, 2020 03 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-32142284
15.
Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA.
Bioorg Med Chem Lett
; 19(24): 6851-4, 2009 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19889539
16.
A Novel LSD1 Inhibitor T-3775440 Disrupts GFI1B-Containing Complex Leading to Transdifferentiation and Impaired Growth of AML Cells.
Mol Cancer Ther
; 16(2): 273-284, 2017 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-27903753
17.
Discovery of a piperidine-4-carboxamide CCR5 antagonist (TAK-220) with highly potent Anti-HIV-1 activity.
J Med Chem
; 49(9): 2784-93, 2006 May 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-16640339
18.
[Late onset epilepsy associated with migration disorder: a case report].
No To Shinkei
; 58(2): 151-4, 2006 Feb.
Artículo
en Japonés
| MEDLINE | ID: mdl-16519112
19.
A case of leptomeningeal carcinomatosis from esophageal basaloid carcinoma diagnosed by quantitative reverse transcription-polymerase chain reaction for carcinoembryonic antigen.
J Gastroenterol
; 40(1): 87-93, 2005 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-15692794
20.
[Complete response in an elderly patient with advanced gastric cancer treated with TS-1].
Gan To Kagaku Ryoho
; 31(13): 2165-8, 2004 Dec.
Artículo
en Japonés
| MEDLINE | ID: mdl-15628764