Detalles de la búsqueda
1.
New furoxan derivatives for the treatment of ocular hypertension.
Bioorg Med Chem Lett
; 27(3): 479-483, 2017 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28027869
2.
Repeated Dosing with NCX1404, a Nitric Oxide-Donating Pregabalin, Re-establishes Normal Nociceptive Responses in Mice with Streptozotocin-Induced Painful Diabetic Neuropathy.
J Pharmacol Exp Ther
; 357(2): 240-7, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26907623
3.
Aging-induced Nrf2-ARE pathway disruption in the subventricular zone drives neurogenic impairment in parkinsonian mice via PI3K-Wnt/ß-catenin dysregulation.
J Neurosci
; 33(4): 1462-85, 2013 Jan 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-23345222
4.
NCX 470 Reduces Intraocular Pressure More Effectively Than Lumigan in Dogs and Enhances Conventional and Uveoscleral Outflow in Non-Human Primates and Human Trabecular Meshwork/Schlemm's Canal Constructs.
J Ocul Pharmacol Ther
; 2023 Dec 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-38088745
5.
NCX 470 Exerts Retinal Cell Protection and Enhances Ophthalmic Artery Blood Flow After Ischemia/Reperfusion Injury of Optic Nerve Head and Retina.
Transl Vis Sci Technol
; 12(9): 22, 2023 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37750744
6.
A new approach to antiglaucoma drugs: carbonic anhydrase inhibitors with or without NO donating moieties. Mechanism of action and preliminary pharmacology.
J Enzyme Inhib Med Chem
; 27(1): 138-47, 2012 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-21815773
7.
NCX 470 Restores Ocular Hemodynamics and Retinal Cell Physiology After ET-1-Induced Ischemia/Reperfusion Injury of Optic Nerve and Retina in Rabbits.
J Ocul Pharmacol Ther
; 38(7): 496-504, 2022 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35787180
8.
Ocular hypotensive activity of BOL-303259-X, a nitric oxide donating prostaglandin F2α agonist, in preclinical models.
Exp Eye Res
; 93(3): 250-5, 2011 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-21396362
9.
NCX 667, a Novel Nitric Oxide Donor, Lowers Intraocular Pressure in Rabbits, Dogs, and Non-Human Primates and Enhances TGFß2-Induced Outflow in HTM/HSC Constructs.
Invest Ophthalmol Vis Sci
; 62(3): 17, 2021 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33704360
10.
NCX 1741, a Novel Nitric Oxide-Donating Phosphodiesterase-5 Inhibitor, Exerts Rapid and Long-Lasting Intraocular Pressure-Lowering in Cynomolgus Monkeys.
J Ocul Pharmacol Ther
; 37(4): 215-222, 2021 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33595367
11.
Combining nitric oxide release with anti-inflammatory activity preserves nigrostriatal dopaminergic innervation and prevents motor impairment in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.
J Neuroinflammation
; 7: 83, 2010 Nov 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-21092260
12.
Characterization of the potent and highly selective A2A receptor antagonists preladenant and SCH 412348 [7-[2-[4-2,4-difluorophenyl]-1-piperazinyl]ethyl]-2-(2-furanyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine] in rodent models of movement disorders and depression.
J Pharmacol Exp Ther
; 330(1): 294-303, 2009 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-19332567
13.
Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma.
Bioorg Med Chem Lett
; 19(23): 6565-70, 2009 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19854054
14.
Prostaglandin analogues and nitric oxide contribution in the treatment of ocular hypertension and glaucoma.
Br J Pharmacol
; 176(8): 1079-1089, 2019 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29669171
15.
Imidazenil: a low efficacy agonist at alpha1- but high efficacy at alpha5-GABAA receptors fail to show anticonvulsant cross tolerance to diazepam or zolpidem.
Neuropharmacology
; 55(2): 148-53, 2008 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-18555494
16.
NCX 6560, a nitric oxide-releasing derivative of atorvastatin, inhibits cholesterol biosynthesis and shows anti-inflammatory and anti-thrombotic properties.
Eur J Pharmacol
; 570(1-3): 115-24, 2007 Sep 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-17632098
17.
Modulation of iNOS expression by a nitric oxide-releasing derivative of the natural antioxidant ferulic acid in activated RAW 264.7 macrophages.
Eur J Pharmacol
; 532(1-2): 162-9, 2006 Feb 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-16443213
18.
Persistent behavioral sensitization to chronic L-DOPA requires A2A adenosine receptors.
J Neurosci
; 22(3): 1054-62, 2002 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-11826134
19.
Intraocular Pressure-Lowering Activity of NCX 470, a Novel Nitric Oxide-Donating Bimatoprost in Preclinical Models.
Invest Ophthalmol Vis Sci
; 56(11): 6558-64, 2015 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-26457541
20.
A nitric oxide (NO)-releasing derivative of gabapentin, NCX 8001, alleviates neuropathic pain-like behavior after spinal cord and peripheral nerve injury.
Br J Pharmacol
; 141(1): 65-74, 2004 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-14662726