Detalles de la búsqueda
1.
Benzo[a]pyrene-Induced Genotoxicity in Rats Is Affected by Co-Exposure to Sudan I by Altering the Expression of Biotransformation Enzymes.
Int J Mol Sci
; 22(15)2021 Jul 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-34360828
2.
Apoferritin/Vandetanib Association Is Long-Term Stable But Does Not Improve Pharmacological Properties of Vandetanib.
Int J Mol Sci
; 22(8)2021 Apr 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-33923880
3.
Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine.
Toxicol Appl Pharmacol
; 366: 64-74, 2019 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30685480
4.
The impact of p53 on aristolochic acid I-induced nephrotoxicity and DNA damage in vivo and in vitro.
Arch Toxicol
; 93(11): 3345-3366, 2019 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31602497
5.
Identification of Human Enzymes Oxidizing the Anti-Thyroid-Cancer Drug Vandetanib and Explanation of the High Efficiency of Cytochrome P450 3A4 in its Oxidation.
Int J Mol Sci
; 20(14)2019 Jul 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31295928
6.
Differentiation-associated urothelial cytochrome P450 oxidoreductase predicates the xenobiotic-metabolizing activity of "luminal" muscle-invasive bladder cancers.
Mol Carcinog
; 57(5): 606-618, 2018 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29323757
7.
Cytochrome b 5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b 5 /P450 reductase null (HBRN) mice.
Arch Toxicol
; 92(4): 1625-1638, 2018 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-29368147
8.
NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene.
Chem Res Toxicol
; 29(8): 1325-34, 2016 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27404282
9.
The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/-) and Trp53(-/-) mice.
Arch Toxicol
; 90(4): 839-51, 2016 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-25995008
10.
Modulation of human cytochrome P450 1A1-mediated oxidation of benzo[a]pyrene by NADPH:cytochrome P450 oxidoreductase and cytochrome b5.
Neuro Endocrinol Lett
; 35 Suppl 2: 105-13, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-25638374
11.
Oxidation of carcinogenic benzo[a]pyrene by human and rat cytochrome P450 1A1 and its influencing by cytochrome b5 - a comparative study.
Neuro Endocrinol Lett
; 34 Suppl 2: 55-63, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-24362093
12.
Cytochrome b5 increases cytochrome P450 3A4-mediated activation of anticancer drug ellipticine to 13-hydroxyellipticine whose covalent binding to DNA is elevated by sulfotransferases and N,O-acetyltransferases.
Chem Res Toxicol
; 25(5): 1075-85, 2012 May 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-22390216
13.
The impact of individual human cytochrome P450 enzymes on oxidative metabolism of anticancer drug lenvatinib.
Biomed Pharmacother
; 145: 112391, 2022 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-34847475
14.
Correction to NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene.
Chem Res Toxicol
; 29(9): 1571, 2016 09 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-27575721
15.
Identification of Enzymes Oxidizing the Tyrosine Kinase Inhibitor Cabozantinib: Cabozantinib Is Predominantly Oxidized by CYP3A4 and Its Oxidation Is Stimulated by cyt b5 Activity.
Biomedicines
; 8(12)2020 Nov 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-33260548
16.
Cytochrome P450 and flavin-containing monooxygenase enzymes are responsible for differential oxidation of the anti-thyroid-cancer drug vandetanib by human and rat hepatic microsomal systems.
Environ Toxicol Pharmacol
; 74: 103310, 2020 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-31837525
17.
Tyrosine kinase inhibitors vandetanib, lenvatinib and cabozantinib modulate oxidation of an anticancer agent ellipticine catalyzed by cytochromes P450 in vitro.
Neuro Endocrinol Lett
; 39(7): 515-524, 2019 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-30860683
18.
Ellipticine-loaded apoferritin nanocarrier retains DNA adduct-based cytochrome P450-facilitated toxicity in neuroblastoma cells.
Toxicology
; 419: 40-54, 2019 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30914192
19.
The impact of chemotherapeutic drugs on the CYP1A1-catalysed metabolism of the environmental carcinogen benzo[a]pyrene: Effects in human colorectal HCT116 TP53(+/+), TP53(+/-) and TP53(-/-) cells.
Toxicology
; 398-399: 1-12, 2018 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29471073
20.
Comparison of human cytochrome P450 1A1-catalysed oxidation of benzo[a]pyrene in prokaryotic and eukaryotic expression systems.
Monatsh Chem
; 148(11): 1959-1969, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-29104317