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1.
Treatment with a VEGFR-2 antibody results in intra-tumor immune modulation and enhances anti-tumor efficacy of PD-L1 blockade in syngeneic murine tumor models.
PLoS One
; 17(7): e0268244, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35849586
2.
Characterization of 7A5: A Human CD137 (4-1BB) Receptor Binding Monoclonal Antibody with Differential Agonist Properties That Promotes Antitumor Immunity.
Mol Cancer Ther
; 19(4): 988-998, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32241872
3.
Bispecific Targeting of PD-1 and PD-L1 Enhances T-cell Activation and Antitumor Immunity.
Cancer Immunol Res
; 8(10): 1300-1310, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32873605
4.
Targeting the TGFß pathway with galunisertib, a TGFßRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade.
J Immunother Cancer
; 6(1): 47, 2018 06 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29866156
5.
Correction to: Discovery and preclinical characterization of the antagonist anti-PD-L1 monoclonal antibody LY3300054.
J Immunother Cancer
; 6(1): 45, 2018 06 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29866166
6.
Discovery and preclinical characterization of the antagonist anti-PD-L1 monoclonal antibody LY3300054.
J Immunother Cancer
; 6(1): 31, 2018 04 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-29712568
7.
Dasatinib (BMS-354825) pharmacokinetics and pharmacodynamic biomarkers in animal models predict optimal clinical exposure.
Clin Cancer Res
; 12(23): 7180-6, 2006 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17145844
8.
Cetuximab preclinical antitumor activity (monotherapy and combination based) is not predicted by relative total or activated epidermal growth factor receptor tumor expression levels.
Mol Cancer Ther
; 5(1): 104-13, 2006 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-16432168
9.
Prediction of active drug plasma concentrations achieved in cancer patients by pharmacodynamic biomarkers identified from the geo human colon carcinoma xenograft model.
Clin Cancer Res
; 11(15): 5558-65, 2005 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16061873
10.
Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays.
J Med Chem
; 47(27): 6658-61, 2004 Dec 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-15615512
11.
Multivalent scaffold proteins as superagonists of TRAIL receptor 2-induced apoptosis.
Mol Cancer Ther
; 12(7): 1235-44, 2013 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-23645592
12.
MEDI3617, a human anti-angiopoietin 2 monoclonal antibody, inhibits angiogenesis and tumor growth in human tumor xenograft models.
Int J Oncol
; 40(5): 1321-30, 2012 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-22327175
13.
Design, synthesis, and structure-activity relationships of tetrahydroquinoline-based farnesyltransferase inhibitors.
Bioorg Med Chem Lett
; 15(7): 1895-9, 2005 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15780629
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