Detalles de la búsqueda
1.
4-{3-[(Pyridin-4-ylmethyl)amino]-[1,2,4]triazolo[4,3-b][1,2,4]triazin-6-yl}phenol: An improved anticancer agent in hepatocellular carcinoma and a selective MDR1/MRP modulator.
Arch Pharm (Weinheim)
; 357(6): e2300704, 2024 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-38442326
2.
Synthesis and evaluation of 99mTc-labeled 1-(2-Pyridyl)piperazine derivatives as radioligands for 5HT7 receptors.
Bioorg Chem
; 135: 106486, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-36965286
3.
Dual action anti-inflammatory/antiviral isoquinoline alkaloids as potent naturally occurring anti-SARS-CoV-2 agents: A combined pharmacological and medicinal chemistry perspective.
Phytother Res
; 37(5): 2168-2186, 2023 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-37039761
4.
Polyethyleneglycol-serine nanoparticles as a novel antidote for organophosphate poisoning: synthesis, characterization, in vitro and in vivo studies.
Drug Chem Toxicol
; 46(5): 915-930, 2023 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-35938408
5.
Discovery of Chalcone-Based Hybrid Structures as High Affinity and Site-Specific Inhibitors against SARS-CoV-2: A Comprehensive Structural Analysis Based on Various Host-Based and Viral Targets.
Int J Mol Sci
; 24(10)2023 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37240149
6.
Papaverine, a promising therapeutic agent for the treatment of COVID-19 patients with underlying cardiovascular diseases (CVDs).
Drug Dev Res
; 83(6): 1246-1250, 2022 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35706384
7.
Synthesis, in silico, in vitro and in vivo evaluations of isatin aroylhydrazones as highly potent anticonvulsant agents.
Bioorg Chem
; 112: 104943, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33964578
8.
Potentiation of Low-Dose Doxorubicin Cytotoxicity by Affecting P-Glycoprotein through Caryophyllane Sesquiterpenes in HepG2 Cells: an in Vitro and in Silico Study.
Int J Mol Sci
; 21(2)2020 Jan 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-31963614
9.
Design, synthesis, in vivo and in silico evaluation of phenacyl triazole hydrazones as new anticonvulsant agents.
Bioorg Chem
; 78: 119-129, 2018 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29550532
10.
New 7-piperazinylquinolones containing (benzo[d]imidazol-2-yl)methyl moiety as potent antibacterial agents.
Mol Divers
; 22(4): 815-825, 2018 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-29881985
11.
Synthesis and biological evaluation of fluconazole analogs with triazole-modified scaffold as potent antifungal agents.
Bioorg Med Chem
; 23(7): 1481-91, 2015 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25740636
12.
Novel triazole alcohol antifungals derived from fluconazole: design, synthesis, and biological activity.
Mol Divers
; 19(1): 15-27, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25182365
13.
Design, synthesis and in vitro study of 5,6-diaryl-1,2,4-triazine-3-ylthioacetate derivatives as COX-2 and ß-amyloid aggregation inhibitors.
Arch Pharm (Weinheim)
; 348(3): 179-87, 2015 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-25690564
14.
Synthesis, docking simulation, biological evaluations and 3D-QSAR study of 5-Aryl-6-(4-methylsulfonyl)-3-(metylthio)-1,2,4-triazine as selective cyclooxygenase-2 inhibitors.
Bioorg Med Chem
; 22(2): 865-73, 2014 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24361187
15.
Imidazolylchromanones containing alkyl side chain as lanosterol 14α-demethylase inhibitors: synthesis, antifungal activity and docking study.
J Enzyme Inhib Med Chem
; 29(2): 263-71, 2014 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-23488742
16.
Development of New PCR Protocols to Detect Genetic Diversity in the Metronidazole Metabolism Genes in Susceptible and Refractory Clinical Samples of Giardia duodenalis.
Acta Parasitol
; 69(1): 1073-1077, 2024 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-38499920
17.
An Overview on Anti-COVID-19 Drug Achievements and Challenges Ahead.
ACS Pharmacol Transl Sci
; 6(9): 1248-1265, 2023 Sep 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-37705590
18.
Benzoindolizidine Alkaloids Tylophorine and Lycorine and Their Analogues with Antiviral, Anti-Inflammatory, and Anticancer Properties: Promises and Challenges.
Biomedicines
; 11(10)2023 Sep 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-37892993
19.
In silico design of a novel peptide-based vaccine against the ubiquitous apicomplexan Toxoplasma gondii using surface antigens.
In Silico Pharmacol
; 11(1): 5, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-36960094
20.
Engineering and design of promising T-cell-based multi-epitope vaccine candidates against leishmaniasis.
Sci Rep
; 13(1): 19421, 2023 11 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-37940672