Detalles de la búsqueda
1.
Cytochrome P450 and UDP-glucuronosyltransferase expressions, activities, and induction abilities in 3D-cultured human renal proximal tubule epithelial cells.
Drug Metab Dispos
; 2024 Jun 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-38866474
2.
Impact of Direction of Transport on the Evaluation of Substrate Recognition of Mouse Multidrug and Toxin Extrusion Protein 1.
Drug Metab Dispos
; 51(5): 583-590, 2023 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36669855
3.
Quantitative Analysis of mRNA and Protein Expression Levels of Aldo-Keto Reductase and Short-Chain Dehydrogenase/Reductase Isoforms in the Human Intestine.
Drug Metab Dispos
; 51(12): 1569-1577, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37722844
4.
Development and Validation of a Proteomic Correlation Profiling Technique to Detect and Identify Enzymes Involved in Metabolism of Drugs of Concern.
Drug Metab Dispos
; 51(7): 824-832, 2023 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-37156625
5.
Improvement of Protein Expression Profile in Three-Dimensional Renal Proximal Tubular Epithelial Cell Spheroids Selected Based on OAT1 Gene Expression: A Potential In Vitro Tool for Evaluating Human Renal Proximal Tubular Toxicity and Drug Disposition.
Drug Metab Dispos
; 51(9): 1177-1187, 2023 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37385755
6.
Characterization of Enzymes Involved in Nintedanib Metabolism in Humans.
Drug Metab Dispos
; 51(6): 733-742, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-36927840
7.
Identification of HSD17B12 as an enzyme catalyzing drug reduction reactions through investigation of nabumetone metabolism.
Arch Biochem Biophys
; 736: 109536, 2023 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36724833
8.
Pharmacokinetic-Interactions of BI 425809, a Novel Glycine Transporter 1 Inhibitor, With Cytochrome P450 and P-Glycoprotein Substrates: Findings From In Vitro Analyses and an Open-Label, Single-Sequence Phase I Study.
J Clin Psychopharmacol
; 43(2): 113-121, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-36700734
9.
Integrated safety analysis of filgotinib treatment for rheumatoid arthritis in patients from Japan over a median of 1.5 years.
Mod Rheumatol
; 33(1): 64-72, 2023 Jan 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-35365828
10.
Safety and efficacy of filgotinib for Japanese patients with RA and inadequate response to MTX: FINCH 1 52-week results and FINCH 4 48-week results.
Mod Rheumatol
; 33(4): 668-679, 2023 Jul 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-35920102
11.
Long-term safety and efficacy of filgotinib treatment for rheumatoid arthritis in Japanese patients naïve to MTX treatment (FINCH 3).
Mod Rheumatol
; 33(4): 657-667, 2023 Jul 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-35921235
12.
A human blood-arachnoid barrier atlas of transporters, receptors, enzymes, and tight junction and marker proteins: Comparison with dog and pig in absolute abundance.
J Neurochem
; 161(2): 187-208, 2022 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-35226354
13.
Meclozine ameliorates skeletal muscle pathology and increases muscle forces in mdx mice.
Biochem Biophys Res Commun
; 592: 87-92, 2022 02 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-35033871
14.
CTGF/CCN2 facilitates LRP4-mediated formation of the embryonic neuromuscular junction.
EMBO Rep
; 21(8): e48462, 2020 08 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-32558157
15.
Regional Differences in the Absolute Abundance of Transporters, Receptors and Tight Junction Molecules at the Blood-Arachnoid Barrier and Blood-Spinal Cord Barrier among Cervical, Thoracic and Lumbar Spines in Dogs.
Pharm Res
; 39(7): 1393-1413, 2022 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-35488144
16.
Functional coupling of organic anion transporter OAT10 (SLC22A13) and monocarboxylate transporter MCT1 (SLC16A1) influencing the transport function of OAT10.
J Pharmacol Sci
; 150(1): 41-48, 2022 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-35926947
17.
Efficacy and safety of filgotinib in Japanese patients with refractory rheumatoid arthritis: Subgroup analyses of a global phase 3 study (FINCH 2).
Mod Rheumatol
; 32(1): 59-67, 2022 01 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33274687
18.
Efficacy and safety of filgotinib in combination with methotrexate in Japanese patients with active rheumatoid arthritis who have an inadequate response to methotrexate: Subpopulation analyses of 24-week data of a global phase 3 study (FINCH 1).
Mod Rheumatol
; 32(2): 263-272, 2022 Feb 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-34910188
19.
Efficacy and safety of filgotinib alone and in combination with methotrexate in Japanese patients with active rheumatoid arthritis and limited or no prior exposure to methotrexate: Subpopulation analyses of 24-week data of a global phase 3 study (FINCH 3).
Mod Rheumatol
; 32(2): 273-283, 2022 Feb 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-34910203
20.
Impact of Direction of Transport on the Evaluation of Inhibition Potencies of Multidrug and Toxin Extrusion Protein 1 Inhibitors.
Drug Metab Dispos
; 49(2): 152-158, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33262224