Detalles de la búsqueda
1.
Physiologically based pharmacokinetic modelling to predict the clinical effect of CYP3A inhibitors/inducers on esaxerenone pharmacokinetics in healthy subjects and subjects with hepatic impairment.
Eur J Clin Pharmacol
; 78(1): 65-73, 2022 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-34415382
2.
Effects of itraconazole and rifampicin on the single-dose pharmacokinetics of the nonsteroidal mineralocorticoid receptor blocker esaxerenone in healthy Japanese subjects.
Br J Clin Pharmacol
; 86(10): 2070-2079, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32250463
3.
Circulating miRNA Signature as a Potential Biomarker for the Prediction of Analgesic Efficacy of Hydromorphone.
Int J Mol Sci
; 20(7)2019 Apr 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-30987164
4.
Intrapulmonary Pharmacokinetics of Laninamivir, a Neuraminidase Inhibitor, after a Single Nebulized Administration of Laninamivir Octanoate in Healthy Japanese Subjects.
Antimicrob Agents Chemother
; 62(1)2018 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29061751
5.
Single- and multiple-dose escalation study to assess pharmacokinetics, pharmacodynamics and safety of oral esaxerenone in healthy Japanese subjects.
Br J Clin Pharmacol
; 84(8): 1821-1829, 2018 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29688582
6.
Correction to: Physiologically based pharmacokinetic modelling to predict the clinical effect of CYP3A inhibitors/inducers on esaxerenone pharmacokinetics in healthy subjects and subjects with hepatic impairment.
Eur J Clin Pharmacol
; 78(1): 75, 2022 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-34494163
7.
Identification of Circulating miRNAs Differentially Regulated by Opioid Treatment.
Int J Mol Sci
; 18(9)2017 Sep 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-28926935
8.
Safety, Tolerability, and Pharmacokinetics of Valemetostat Tablets and the Effect of Food on Valemetostat Pharmacokinetics in Healthy Subjects: Two Phase 1 Studies.
Clin Pharmacol Drug Dev
; 13(1): 77-86, 2024 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37565616
9.
Population pharmacokinetics of esaxerenone, a novel non-steroidal mineralocorticoid receptor blocker, in patients with essential hypertension, patients with diabetic nephropathy, and healthy volunteers.
Drug Metab Pharmacokinet
; 52: 100516, 2023 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-37690271
10.
Steady-State Pharmacokinetics of Intravenous Hydromorphone in Japanese Patients With Renal Impairment and Cancer Pain.
J Palliat Med
; 26(6): 768-775, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-36579915
11.
Effect of itraconazole and fluconazole on the pharmacokinetics of valemetostat: An open-label, phase I study in healthy subjects.
Clin Transl Sci
; 16(11): 2153-2162, 2023 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-37705321
12.
Pharmacokinetics and Bioequivalence of Mirogabalin Orally Disintegrating Tablets and Conventional Tablets in Healthy Japanese Participants.
Clin Pharmacol Drug Dev
; 12(10): 985-990, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37312273
13.
Safety, Tolerability and Pharmacokinetics of Single and Multiple Doses of Mirogabalin in Healthy Chinese Participants: A Randomized, Double-Blind, Placebo-Controlled Study.
Adv Ther
; 40(4): 1628-1643, 2023 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36790683
14.
DS-5670a, a novel mRNA-encapsulated lipid nanoparticle vaccine against severe acute respiratory syndrome coronavirus 2: Results from a phase 2 clinical study.
Vaccine
; 41(38): 5525-5534, 2023 08 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-37586958
15.
Intrapulmonary distribution and pharmacokinetics of laninamivir, a neuraminidase inhibitor, after a single inhaled administration of its prodrug, laninamivir octanoate, in healthy volunteers.
Antimicrob Agents Chemother
; 56(7): 3873-8, 2012 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-22526307
16.
Association study of genetic polymorphisms of drug transporters, SLCO1B1, SLCO1B3 and ABCC2, in African-Americans, Hispanics and Caucasians and olmesartan exposure.
J Hum Genet
; 57(8): 531-44, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22695893
17.
Bioequivalence of Esaxerenone Conventional Tablet and Orally Disintegrating Tablet: Two Single-Dose Crossover Studies in Healthy Japanese Men.
Clin Pharmacol Drug Dev
; 11(8): 957-965, 2022 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35315257
18.
Model-based assessments of CYP3A-mediated drug-drug interaction risk of milademetan.
Clin Transl Sci
; 14(6): 2220-2230, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34080309
19.
Effects of Repeated Oral Administration of Esaxerenone on the Pharmacokinetics of Midazolam in Healthy Japanese Males.
Eur J Drug Metab Pharmacokinet
; 46(5): 685-694, 2021 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-34383278
20.
Pharmacokinetic interactions of esaxerenone with amlodipine and digoxin in healthy Japanese subjects.
BMC Pharmacol Toxicol
; 21(1): 55, 2020 07 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-32727577