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1.
Pharmacological evaluation of novel (6-aminopyridin-3-yl)(4-(pyridin-2-yl)piperazin-1-yl) methanone derivatives as TRPV4 antagonists for the treatment of pain.
Bioorg Med Chem
; 25(7): 2177-2190, 2017 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28284871
2.
Discovery of novel 2',4'-dimethyl-[4,5'-bithiazol]-2-yl amino derivatives as orally bioavailable TRPV4 antagonists for the treatment of pain: Part 2.
Bioorg Med Chem Lett
; 26(20): 4936-4941, 2016 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27634196
3.
Discovery of novel 2',4'-dimethyl-[4,5'-bithiazol]-2-yl amino derivatives as orally bioavailable TRPV4 antagonists for the treatment of pain: Part 1.
Bioorg Med Chem Lett
; 26(20): 4930-4935, 2016 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27637151
4.
Design, synthesis, and binding mode prediction of 2-pyridone-based selective CB2 receptor agonists.
Bioorg Med Chem
; 21(7): 2045-55, 2013 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23395112
5.
Selective CB2 agonists with anti-pruritic activity: discovery of potent and orally available bicyclic 2-pyridones.
Bioorg Med Chem
; 21(11): 3154-63, 2013 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23623258
6.
Trifluoromethyl Dihydrothiazine-Based ß-Secretase (BACE1) Inhibitors with Robust Central ß-Amyloid Reduction and Minimal Covalent Binding Burden.
ChemMedChem
; 14(22): 1894-1910, 2019 11 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-31657130
7.
Discovery of an Extremely Potent Thiazine-Based ß-Secretase Inhibitor with Reduced Cardiovascular and Liver Toxicity at a Low Projected Human Dose.
J Med Chem
; 62(20): 9331-9337, 2019 10 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-31549838
8.
Rational Design of Novel 1,3-Oxazine Based ß-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust Aß Reduction in the Brain.
J Med Chem
; 61(12): 5122-5137, 2018 06 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-29733614
9.
Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine ß-Secretase (BACE1) Inhibitors via Active Conformation Stabilization.
J Med Chem
; 61(13): 5525-5546, 2018 07 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29775538
10.
Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications.
J Med Chem
; 49(3): 1080-100, 2006 Feb 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-16451073
11.
Structure-activity relationship studies and discovery of a potent transient receptor potential vanilloid (TRPV1) antagonist 4-[3-chloro-5-[(1S)-1,2-dihydroxyethyl]-2-pyridyl]-N-[5-(trifluoromethyl)-2-pyridyl]-3,6-dihydro-2H-pyridine-1-carboxamide (V116517) as a clinical candidate for pain management.
J Med Chem
; 57(15): 6781-94, 2014 Aug 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-25057800
12.
Design, synthesis, and SAR studies of mefloquine-based ligands as potential antituberculosis agents.
ChemMedChem
; 1(6): 593-7, 2006 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-16892398
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