Detalles de la búsqueda
1.
Discovery of N-(6-(5-fluoro-2-(piperidin-1-yl)phenyl)pyridazin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)methanesulfonamide as a brain-permeable and metabolically stable kynurenine monooxygenase inhibitor.
Bioorg Med Chem Lett
; 44: 128115, 2021 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34015507
2.
N-(6-phenylpyridazin-3-yl)benzenesulfonamides as highly potent, brain-permeable, and orally active kynurenine monooxygenase inhibitors.
Bioorg Med Chem Lett
; 33: 127753, 2021 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33359168
3.
Synthesis and pharmacological evaluation of 11-(1,6-dimethyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-dibenzo[b,e][1,4]diazepines with clozapine-like receptor occupancy at dopamine D1/D2 receptor.
Bioorg Med Chem Lett
; 30(21): 127563, 2020 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32976928
4.
Identification of 2-fluoro-8-methyl-11-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-dibenzo[b,e][1,4]diazepine with clozapine-like mixed activities at muscarinic acetylcholine, dopamine, and serotonin receptors.
Bioorg Med Chem Lett
; 40: 127911, 2021 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33691168
5.
Synthesis and biological evaluation of novel orally available 1-phenyl-6-aminouracils containing dimethyldihydrobenzofuranol structure for the treatment of allergic skin diseases.
Bioorg Med Chem Lett
; 26(4): 1292-5, 2016 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26786694
6.
Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility.
Bioorg Med Chem Lett
; 23(3): 669-72, 2013 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23265901
7.
Synthesis of novel benzo-fused heteroaryl derivatives as Ca²âº/calmodulin-dependent protein kinase II inhibitors.
Chem Pharm Bull (Tokyo)
; 61(10): 1094-7, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-24088703
8.
Synthesis and structure based optimization of 2-(4-phenoxybenzoyl)-5-hydroxyindole as a novel CaMKII inhibitor.
Bioorg Med Chem
; 20(23): 6840-7, 2012 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23088910
9.
Circadian rhythm of metabolic oscillation in suprachiasmatic nucleus depends on the mitochondrial oxidation state, reflected by cytochrome C oxidase and lactate dehydrogenase.
J Neurosci Res
; 89(6): 929-35, 2011 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-21416482
10.
Circadian rhythm of enolase in suprachiasmatic nucleus depends on mitochondrial function.
J Neurosci Res
; 89(6): 936-44, 2011 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-21416483
11.
Structure and activity relationship of 2-(substituted benzoyl)-hydroxyindoles as novel CaMKII inhibitors.
Bioorg Med Chem Lett
; 21(5): 1456-8, 2011 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21292482
12.
Synthesis and structure-activity relationship of tricyclic carboxylic acids as novel anti-histamines.
Bioorg Med Chem
; 19(9): 3005-21, 2011 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21470866
13.
5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidines as novel class of potent and highly selective CaMKII inhibitors.
Bioorg Med Chem Lett
; 20(22): 6696-8, 2010 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20875738
14.
Structural analysis reveals TLR7 dynamics underlying antagonism.
Nat Commun
; 11(1): 5204, 2020 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33060576
15.
Synthesis and structure-activity relationships of phenothiazine carboxylic acids having pyrimidine-dione as novel histamine H(1) antagonists.
Bioorg Med Chem Lett
; 19(10): 2766-71, 2009 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19362477
16.
Enhanced neurogenesis from neural progenitor cells with G1/S-phase cell cycle arrest is mediated by transforming growth factor beta1.
Eur J Neurosci
; 28(6): 1049-59, 2008 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-18783370
17.
Increase in dopaminergic neurons from mouse embryonic stem cell-derived neural progenitor/stem cells is mediated by hypoxia inducible factor-1alpha.
J Neurosci Res
; 86(11): 2353-62, 2008 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18438929
18.
Increase in neurogenesis and neuroblast migration after a small intracerebral hemorrhage in rats.
Neurosci Lett
; 425(2): 114-9, 2007 Sep 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-17826909
19.
Synthesis and biological evaluation of novel 9-substituted-8-hydroxyadenine derivatives as potent interferon inducers.
J Med Chem
; 49(6): 2088-95, 2006 Mar 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-16539397
20.
Discovery of 8-hydroxyadenines as a novel type of interferon inducer.
J Med Chem
; 45(25): 5419-22, 2002 Dec 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-12459008