Detalles de la búsqueda
1.
Commensals Suppress Intestinal Epithelial Cell Retinoic Acid Synthesis to Regulate Interleukin-22 Activity and Prevent Microbial Dysbiosis.
Immunity
; 49(6): 1103-1115.e6, 2018 12 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-30566883
2.
Drugs Form Ternary Complexes with Human Liver Fatty Acid Binding Protein 1 (FABP1) and FABP1 Binding Alters Drug Metabolism.
Mol Pharmacol
; 105(6): 395-410, 2024 May 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-38580446
3.
Raising NAD+ Level Stimulates Short-Chain Dehydrogenase/Reductase Proteins to Alleviate Heart Failure Independent of Mitochondrial Protein Deacetylation.
Circulation
; 148(25): 2038-2057, 2023 12 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-37965787
4.
Physiologically Based Pharmacokinetic (PBPK) Modeling of small molecules: How Much Progress Have We Made?
Drug Metab Dispos
; 2024 Feb 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-38326033
5.
LX-2 Stellate Cells Are a Model System for Investigating the Regulation of Hepatic Vitamin A Metabolism and Respond to Tumor Necrosis Factor α and Interleukin 1ß.
Drug Metab Dispos
; 52(5): 442-454, 2024 Apr 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-38485281
6.
The ADME characteristics of siRNA therapeutics and the opportunity to predict disposition in pregnant women.
Drug Metab Dispos
; 2024 May 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-38811157
7.
Effect of isotretinoin on CYP2D6 and CYP3A activity in patients with severe acne.
Br J Clin Pharmacol
; 90(3): 759-768, 2024 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-37864393
8.
Impact of Intracellular Lipid Binding Proteins on Endogenous and Xenobiotic Ligand Metabolism and Disposition.
Drug Metab Dispos
; 51(6): 700-717, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-37012074
9.
The Utility of Mixed Effects Models in the Evaluation of Complex Genomic Traits In Vitro.
Drug Metab Dispos
; 51(11): 1455-1462, 2023 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-37562955
10.
CYP2D6 Activity Is Correlated with Changes in Plasma Concentrations of Taurocholic Acid during Pregnancy and Postpartum in CYP2D6 Extensive Metabolizers.
Drug Metab Dispos
; 51(11): 1474-1482, 2023 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-37550070
11.
Retinoic acid regulates pyruvate dehydrogenase kinase 4 (Pdk4) to modulate fuel utilization in the adult heart: Insights from wild-type and ß-carotene 9',10' oxygenase knockout mice.
FASEB J
; 36(9): e22513, 2022 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-36004605
12.
Incorporating Uremic Solute-mediated Inhibition of OAT1/3 Improves PBPK Prediction of Tenofovir Renal and Systemic Disposition in Patients with Severe Kidney Disease.
Pharm Res
; 40(11): 2597-2606, 2023 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-37704895
13.
Discovery and Visualization of Uncharacterized Drug-Protein Adducts Using Mass Spectrometry.
Anal Chem
; 94(8): 3501-3509, 2022 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35184559
14.
Epithelium intrinsic vitamin A signaling co-ordinates pathogen clearance in the gut via IL-18.
PLoS Pathog
; 16(4): e1008360, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32330185
15.
Isotretinoin and its Metabolites Alter mRNA of Multiple Enzyme and Transporter Genes In Vitro, but Downregulation of Organic Anion Transporting Polypeptide Does Not Translate to the Clinic.
Drug Metab Dispos
; 50(7): 1042-1052, 2022 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35545255
16.
Impact of vitamin A transport and storage on intestinal retinoid homeostasis and functions.
J Lipid Res
; 62: 100046, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-33587919
17.
Predicting Maternal-Fetal Disposition of Fentanyl Following Intravenous and Epidural Administration Using Physiologically Based Pharmacokinetic Modeling.
Drug Metab Dispos
; 49(11): 1003-1015, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34407992
18.
Aldehyde Oxidase Contributes to All-Trans-Retinoic Acid Biosynthesis in Human Liver.
Drug Metab Dispos
; 49(3): 202-211, 2021 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-33355213
19.
Knockout of Cyp26a1 and Cyp26b1 during postnatal life causes reduced lifespan, dermatitis, splenomegaly, and systemic inflammation in mice.
FASEB J
; 34(12): 15788-15804, 2020 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33105029
20.
Pregnancy Has No Clinically Significant Effect on the Pharmacokinetics of Bupropion or Its Metabolites.
Ther Drug Monit
; 43(6): 780-788, 2021 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33814540