Detalles de la búsqueda
1.
Biodistribution and delivery of oligonucleotide therapeutics to the central nervous system: Advances, challenges, and future perspectives.
Biopharm Drug Dispos
; 44(1): 26-47, 2023 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-36336817
2.
Fc-independent functions of anti-CTLA-4 antibodies contribute to anti-tumor efficacy.
Cancer Immunol Immunother
; 71(10): 2421-2431, 2022 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-35237846
3.
An Automated Multicycle Immunoaffinity Enrichment Approach Developed for Sensitive Mouse IgG1 Antibody Drug Analysis in Mouse Plasma Using LC/MS/MS.
Anal Chem
; 93(16): 6348-6354, 2021 04 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-33848130
4.
Selective Acetyl-CoA Carboxylase 1 Inhibitor Improves Hepatic Steatosis and Hepatic Fibrosis in a Preclinical Nonalcoholic Steatohepatitis Model.
J Pharmacol Exp Ther
; 379(3): 280-289, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34535562
5.
Discovery of a novel series of GPR119 agonists: Design, synthesis, and biological evaluation of N-(Piperidin-4-yl)-N-(trifluoromethyl)pyrimidin-4-amine derivatives.
Bioorg Med Chem
; 41: 116208, 2021 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34010766
6.
Discovery of a novel series of indolinylpyrimidine-based GPR119 agonists: Elimination of ether-a-go-go-related gene liability using a hydrogen bond acceptor-focused approach.
Bioorg Med Chem
; 34: 116034, 2021 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33548803
7.
Characterization of plasma protein binding in two mouse models of humanized liver, PXB mouse and humanized TK-NOG mouse.
Xenobiotica
; 51(1): 51-60, 2021 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-32779988
8.
Direct Drug Delivery of Low-Permeable Compounds to the Central Nervous System Via Intranasal Administration in Rats and Monkeys.
Pharm Res
; 36(5): 76, 2019 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30937626
9.
Prediction of human pharmacokinetics of long half-life compounds using chimeric mice with humanised liver.
Xenobiotica
; 49(12): 1379-1387, 2019 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-30744481
10.
Application of unbound liver-to-plasma concentration ratio to quantitative projection of cytochrome P450-mediated drug-drug interactions using physiologically based pharmacokinetic modelling approach.
Xenobiotica
; 49(11): 1251-1259, 2019 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-30516093
11.
Quantitative prediction of the extent of drug-drug interaction using a physiologically based pharmacokinetic model that includes inhibition of drug metabolism determined in cryopreserved hepatocytes.
Xenobiotica
; 48(8): 770-780, 2018 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-28851254
12.
Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling of the Glucagon-Like Peptide-1 Receptor Agonist Exenatide to Characterize Its Antiobesity Effects in Diet-Induced Obese Mice.
J Pharmacol Exp Ther
; 362(3): 441-449, 2017 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28698254
13.
Discovery of novel 5-oxa-2,6-diazaspiro[3.4]oct-6-ene derivatives as potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonists for treatment of type 2 diabetes mellitus.
Bioorg Med Chem
; 25(15): 4175-4193, 2017 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28642028
14.
Discovery of novel somatostatin receptor subtype 5 (SSTR5) antagonists: Pharmacological studies and design to improve pharmacokinetic profiles and human Ether-a-go-go-related gene (hERG) inhibition.
Bioorg Med Chem
; 25(15): 4153-4162, 2017 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28622905
15.
Unbound liver concentration is the true inhibitor concentration that determines cytochrome P450-mediated drug-drug interactions in rat liver.
Xenobiotica
; 47(6): 488-497, 2017 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-27435455
16.
Comparison of predictability for human pharmacokinetics parameters among monkeys, rats, and chimeric mice with humanised liver.
Xenobiotica
; 47(12): 1052-1063, 2017 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-27892765
17.
A novel membrane fusion-mediated plant immunity against bacterial pathogens.
Genes Dev
; 23(21): 2496-506, 2009 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19833761
18.
Use of proximal side-hole micro-balloon catheter in transcatheter hepatic arterial chemoembolization.
Minim Invasive Ther Allied Technol
; 26(6): 372-376, 2017 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-28497709
19.
A successful case of deceased donor liver transplantation for a patient with intrahepatic arterioportal fistula.
Hepatol Res
; 46(13): 1409-1415, 2016 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26990240
20.
Evaluation of Ki-67 index in EUS-FNA specimens for the assessment of malignancy risk in pancreatic neuroendocrine tumors.
Endoscopy
; 46(1): 32-8, 2014 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-24218309