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1.
p53-related protein kinase confers poor prognosis and represents a novel therapeutic target in multiple myeloma.
Blood
; 129(10): 1308-1319, 2017 03 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28082445
2.
Establishment of a human hepatocellular cell line capable of maintaining long-term replication of hepatitis B virus.
Int Immunol
; 29(3): 109-120, 2017 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28338936
3.
Vepafestinib is a pharmacologically advanced RET-selective inhibitor with high CNS penetration and inhibitory activity against RET solvent front mutations.
Nat Cancer
; 4(9): 1345-1361, 2023 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37743366
4.
Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation.
J Biol Chem
; 285(7): 4587-94, 2010 Feb 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-19864428
5.
Cell death induction in resting lymphocytes by pan-Cdk inhibitor, but not by Cdk4/6 selective inhibitor.
Invest New Drugs
; 29(5): 921-31, 2011 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-20524038
6.
Potent anti-tumor activity of a macrocycle-quinoxalinone class pan-Cdk inhibitor in vitro and in vivo.
Invest New Drugs
; 29(4): 534-43, 2011 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-20084424
7.
Structures of the PKC-iota kinase domain in its ATP-bound and apo forms reveal defined structures of residues 533-551 in the C-terminal tail and their roles in ATP binding.
Acta Crystallogr D Biol Crystallogr
; 66(Pt 5): 577-83, 2010 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-20445233
8.
Imidazopyridine derivatives as potent and selective Polo-like kinase (PLK) inhibitors.
Bioorg Med Chem Lett
; 19(16): 4673-8, 2009 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19589677
9.
Screening for inhibitor of episomal DNA identified dicumarol as a hepatitis B virus inhibitor.
PLoS One
; 14(2): e0212233, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-30779774
10.
Identification of novel benzimidazole series of potent and selective ORL1 antagonists.
Bioorg Med Chem Lett
; 18(11): 3278-81, 2008 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18468891
11.
Author Correction: Vepafestinib is a pharmacologically advanced RET-selective inhibitor with high CNS penetration and inhibitory activity against RET solvent front mutations.
Nat Cancer
; 4(10): 1526, 2023 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-37814012
12.
Identification of a novel spiropiperidine opioid receptor-like 1 antagonist class by a focused library approach featuring 3D-pharmacophore similarity.
J Med Chem
; 49(3): 847-9, 2006 Feb 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-16451050
13.
Recent advances in the development of selective small molecule inhibitors for cyclin-dependent kinases.
Curr Top Med Chem
; 5(2): 167-79, 2005.
Artículo
en Inglés
| MEDLINE | ID: mdl-15853645
14.
MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil.
Cancer Biol Ther
; 9(7): 514-22, 2010 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20107315
15.
MK-5108, a highly selective Aurora-A kinase inhibitor, shows antitumor activity alone and in combination with docetaxel.
Mol Cancer Ther
; 9(1): 157-66, 2010 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-20053775
16.
Biological characterization of 2-aminothiazole-derived Cdk4/6 selective inhibitor in vitro and in vivo.
Cell Cycle
; 9(8): 1590-600, 2010 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20372067
17.
Identification of an orally active opioid receptor-like 1 (ORL1) receptor antagonist 4-{3-[(2R)-2,3-dihydroxypropyl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}-1-[(1S,3S,4R)-spiro[bicyclo[2.2.1]heptane-2,1'-cyclopropan]-3-ylmethyl]piperidine as clinical candidate.
J Med Chem
; 52(14): 4091-4, 2009 Jul 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-19537798
18.
Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents.
Mol Cancer Ther
; 8(11): 2992-3000, 2009 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-19887545
19.
Identification of potent 5-pyrimidinyl-2-aminothiazole CDK4, 6 inhibitors with significant selectivity over CDK1, 2, 5, 7, and 9.
Bioorg Med Chem Lett
; 16(14): 3751-4, 2006 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16682184
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