Detalles de la búsqueda
1.
Physiologically-based pharmacokinetic modelling of a CYP2C19 substrate, BMS-823778, utilizing pharmacogenetic data.
Br J Clin Pharmacol
; 84(6): 1335-1345, 2018 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-29469197
2.
Current Approaches for Absorption, Distribution, Metabolism, and Excretion Characterization of Antibody-Drug Conjugates: An Industry White Paper.
Drug Metab Dispos
; 44(5): 617-23, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26669328
3.
Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro.
Drug Metab Dispos
; 44(3): 320-8, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-26714763
4.
Characterization of ADME properties of [(14)C]asunaprevir (BMS-650032) in humans.
Xenobiotica
; 46(1): 52-64, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-26153443
5.
Quantitative analysis of polyethylene glycol (PEG) and PEGylated proteins in animal tissues by LC-MS/MS coupled with in-source CID.
Anal Chem
; 86(15): 7642-9, 2014 Aug 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-25003239
6.
Identification of the oxidative and conjugative enzymes involved in the biotransformation of brivanib.
Drug Metab Dispos
; 40(1): 219-26, 2012 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-21989950
7.
In vitro and in vivo metabolism and pharmacokinetics of BMS-562086, a potent and orally bioavailable corticotropin-releasing factor-1 receptor antagonist.
Drug Metab Dispos
; 40(6): 1093-103, 2012 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-22381334
8.
Characterization of the in vitro and in vivo metabolism and disposition and cytochrome P450 inhibition/induction profile of saxagliptin in human.
Drug Metab Dispos
; 40(7): 1345-56, 2012 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-22496391
9.
Metabolic chiral inversion of brivanib and its relevance to safety and pharmacology.
Drug Metab Dispos
; 40(12): 2374-80, 2012 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-22983304
10.
In vitro characterization of the metabolic pathways and cytochrome P450 inhibition and induction potential of BMS-690514, an ErbB/vascular endothelial growth factor receptor inhibitor.
Drug Metab Dispos
; 39(9): 1658-67, 2011 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-21673131
11.
Metabolism and disposition of [14C]brivanib alaninate after oral administration to rats, monkeys, and humans.
Drug Metab Dispos
; 39(5): 891-903, 2011 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-21289073
12.
Mechanistic studies on a P450-mediated rearrangement of BMS-690514: conversion of a pyrrolotriazine to a hydroxypyridotriazine.
Chem Res Toxicol
; 24(1): 125-34, 2011 Jan 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-21080678
13.
Metabolism of [2-14C]p-hydroxyphenyl acetic acid in rat, monkey and human hepatocytes and in bile-duct cannulated rats.
Xenobiotica
; 41(4): 312-9, 2011 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-21143006
14.
Disposition of [1'-(14)C]stavudine after oral administration to humans.
Drug Metab Dispos
; 38(4): 655-66, 2010 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-20053818
15.
Metabolism and disposition of [14C]BMS-690514 after oral administration to rats, rabbits, and dogs.
Drug Metab Dispos
; 38(7): 1189-201, 2010 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-20363952
16.
Metabolism and disposition of [14C]BMS-690514, an ErbB/vascular endothelial growth factor receptor inhibitor, after oral administration to humans.
Drug Metab Dispos
; 38(11): 2049-59, 2010 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-20668249
17.
Lysosomal P-gp-MDR1 Confers Drug Resistance of Brentuximab Vedotin and Its Cytotoxic Payload Monomethyl Auristatin E in Tumor Cells.
Front Pharmacol
; 10: 749, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31379564
18.
Lacteal secretion, fetal and maternal tissue distribution of dasatinib in rats.
Drug Metab Dispos
; 36(12): 2564-70, 2008 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-18787054
19.
Biotransformation of [14C]dasatinib: in vitro studies in rat, monkey, and human and disposition after administration to rats and monkeys.
Drug Metab Dispos
; 36(7): 1341-56, 2008 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-18420785
20.
Metabolism and disposition of dasatinib after oral administration to humans.
Drug Metab Dispos
; 36(7): 1357-64, 2008 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-18420784