Detalles de la búsqueda
1.
High-Dose Acetaminophen with Concurrent CYP2E1 Inhibition Has Profound Anticancer Activity without Liver Toxicity.
J Pharmacol Exp Ther
; 388(1): 209-217, 2024 01 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-37918853
2.
Role of HNF4alpha-cMyc interaction in liver regeneration and recovery after acetaminophen-induced acute liver injury.
Hepatology
; 78(4): 1106-1117, 2023 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37021787
3.
The chemokine CXCL14 is a novel early prognostic biomarker for poor outcome in acetaminophen-induced acute liver failure.
Hepatology
; 2023 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37910653
4.
The thrombopoietin mimetic JNJ-26366821 reduces the late injury and accelerates the onset of liver recovery after acetaminophen-induced liver injury in mice.
Arch Toxicol
; 98(6): 1843-1858, 2024 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-38551724
5.
Central mechanisms of acetaminophen hepatotoxicity: mitochondrial dysfunction by protein adducts and oxidant stress.
Drug Metab Dispos
; 2023 Aug 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-37567742
6.
The mitochondrial calcium uniporter mediates mitochondrial Fe2+ uptake and hepatotoxicity after acetaminophen.
Toxicol Appl Pharmacol
; 479: 116722, 2023 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37848124
7.
Nrf2 as a therapeutic target in acetaminophen hepatotoxicity: A case study with sulforaphane.
J Biochem Mol Toxicol
; 37(12): e23505, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37598316
8.
Dose-dependent pleiotropic role of neutrophils during acetaminophen-induced liver injury in male and female mice.
Arch Toxicol
; 97(5): 1397-1412, 2023 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36928416
9.
Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity.
J Hepatol
; 77(1): 71-83, 2022 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35131407
10.
The role of Iron in lipid peroxidation and protein nitration during acetaminophen-induced liver injury in mice.
Toxicol Appl Pharmacol
; 445: 116043, 2022 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35513057
11.
Platanosides, a Potential Botanical Drug Combination, Decrease Liver Injury Caused by Acetaminophen Overdose in Mice.
J Nat Prod
; 85(7): 1779-1788, 2022 07 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-35815804
12.
Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose.
Arch Toxicol
; 96(2): 453-465, 2022 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34978586
13.
Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice.
Arch Toxicol
; 96(1): 305-320, 2022 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34724096
14.
Human Wharton's Jelly-derived mesenchymal stem cells prevent acetaminophen-induced liver injury in a mouse model unlike human dermal fibroblasts.
Arch Toxicol
; 96(12): 3315-3329, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-36057886
15.
Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms.
PLoS Comput Biol
; 16(6): e1007622, 2020 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-32484845
16.
Impaired protein adduct removal following repeat administration of subtoxic doses of acetaminophen enhances liver injury in fed mice.
Arch Toxicol
; 95(4): 1463-1473, 2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33458793
17.
Delayed administration of N-acetylcysteine blunts recovery after an acetaminophen overdose unlike 4-methylpyrazole.
Arch Toxicol
; 95(10): 3377-3391, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34420083
18.
A comprehensive weight of evidence assessment of published acetaminophen genotoxicity data: Implications for its carcinogenic hazard potential.
Regul Toxicol Pharmacol
; 122: 104892, 2021 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-33592196
19.
Assessment of the biochemical pathways for acetaminophen toxicity: Implications for its carcinogenic hazard potential.
Regul Toxicol Pharmacol
; 120: 104859, 2021 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-33388367
20.
Receptor-Interacting Serine/Threonine-Protein Kinase 3 (RIPK3)-Mixed Lineage Kinase Domain-Like Protein (MLKL)-Mediated Necroptosis Contributes to Ischemia-Reperfusion Injury of Steatotic Livers.
Am J Pathol
; 189(7): 1363-1374, 2019 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-31026418