Detalles de la búsqueda
1.
Complement factor B is critical for sub-RPE deposit accumulation in a model of Doyne honeycomb retinal dystrophy with features of age-related macular degeneration.
Hum Mol Genet
; 32(2): 204-217, 2023 01 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35943778
2.
Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.
Proc Natl Acad Sci U S A
; 116(16): 7926-7931, 2019 04 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-30926668
3.
Small-molecule factor D inhibitors targeting the alternative complement pathway.
Nat Chem Biol
; 12(12): 1105-1110, 2016 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-27775713
4.
Specific correlation between the major chromosome 10q26 haplotype conferring risk for age-related macular degeneration and the expression of HTRA1.
Mol Vis
; 23: 318-333, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28659708
5.
Pharmacologic uncoupling of angiogenesis and inflammation during initiation of pathological corneal neovascularization.
J Biol Chem
; 286(52): 44965-75, 2011 Dec 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-22072717
6.
Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
J Med Chem
; 63(11): 5697-5722, 2020 06 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32073845
7.
PCR primers with enhanced specificity for nematode-trapping fungi (Orbiliales).
Microb Ecol
; 58(1): 117-28, 2009 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-18931821
8.
Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway.
J Med Chem
; 62(9): 4656-4668, 2019 05 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-30995036
9.
Selective cell adhesion inhibitors: Barbituric acid based alpha4beta7--MAdCAM inhibitors.
Bioorg Med Chem Lett
; 18(7): 2509-12, 2008 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18331794
10.
Amount of Mononuclear Phagocyte Infiltrate Does Not Predict Area of Experimental Choroidal Neovascularization (CNV).
J Ocul Pharmacol Ther
; 34(7): 489-499, 2018 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-30188257
11.
Nonclinical Safety Evaluation of scAAV8-RLBP1 for Treatment of RLBP1 Retinitis Pigmentosa.
Mol Ther Methods Clin Dev
; 8: 105-120, 2018 Mar 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-29359172
12.
Induction of Ocular Complement Activation by Inflammatory Stimuli and Intraocular Inhibition of Complement Factor D in Animal Models.
Invest Ophthalmol Vis Sci
; 59(2): 940-951, 2018 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29450541
13.
The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration.
J Med Chem
; 61(4): 1622-1635, 2018 02 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-29400470
14.
Quantitation of peripheral blood markers of rat experimental autoimmune encephalomyelitis.
Autoimmunity
; 40(5): 355-65, 2007 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-17612897
15.
Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo.
J Med Chem
; 60(13): 5717-5735, 2017 07 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-28621538
16.
Long-acting protein drugs for the treatment of ocular diseases.
Nat Commun
; 8: 14837, 2017 03 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-28332616
17.
Design, synthesis, and progress toward optimization of potent small molecule antagonists of CC chemokine receptor 8 (CCR8).
J Med Chem
; 49(9): 2669-72, 2006 May 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-16640325
18.
Mice deficient in PKC theta demonstrate impaired in vivo T cell activation and protection from T cell-mediated inflammatory diseases.
Autoimmunity
; 39(6): 469-78, 2006 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-17060026
19.
Discovery of Oral VEGFR-2 Inhibitors with Prolonged Ocular Retention That Are Efficacious in Models of Wet Age-Related Macular Degeneration.
J Med Chem
; 58(23): 9273-86, 2015 Dec 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-26568411
20.
AAV-mediated RLBP1 gene therapy improves the rate of dark adaptation in Rlbp1 knockout mice.
Mol Ther Methods Clin Dev
; 2: 15022, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-26199951