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1.
Activation of GPR40 attenuates chronic inflammation induced impact on pancreatic ß-cells health and function.
BMC Cell Biol
; 15: 24, 2014 Jun 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-24974801
2.
CNX-012-570, a direct AMPK activator provides strong glycemic and lipid control along with significant reduction in body weight; studies from both diet-induced obese mice and db/db mice models.
Cardiovasc Diabetol
; 13: 27, 2014 Jan 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-24460834
3.
Chronic glucolipotoxic conditions in pancreatic islets impair insulin secretion due to dysregulated calcium dynamics, glucose responsiveness and mitochondrial activity.
BMC Cell Biol
; 14: 31, 2013 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23815372
4.
A novel GPR40 agonist, CNX-011-67, suppresses glucagon secretion in pancreatic islets under chronic glucolipotoxic conditions in vitro.
BMC Res Notes
; 7: 595, 2014 Sep 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-25186493
5.
Inhibition of neutral sphingomyelinases in skeletal muscle attenuates fatty-acid induced defects in metabolism and stress.
Springerplus
; 3: 255, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24892004
6.
Integrated analysis of chronic lipotoxicity on muscle metabolism and stress and its reversal by antioxidants.
Springerplus
; 3: 251, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24936385
7.
CNX-011-67, a novel GPR40 agonist, enhances glucose responsiveness, insulin secretion and islet insulin content in n-STZ rats and in islets from type 2 diabetic patients.
BMC Pharmacol Toxicol
; 15: 19, 2014 Mar 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-24666736
8.
A novel 11ß-hydroxysteroid dehydrogenase type1 inhibitor CNX-010-49 improves hyperglycemia, lipid profile and reduces body weight in diet induced obese C57B6/J mice with a potential to provide cardio protective benefits.
BMC Pharmacol Toxicol
; 15: 43, 2014 Aug 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-25098735
9.
CNX-013-B2, a unique pan tissue acting rexinoid, modulates several nuclear receptors and controls multiple risk factors of the metabolic syndrome without risk of hypertriglyceridemia, hepatomegaly and body weight gain in animal models.
Diabetol Metab Syndr
; 6(1): 83, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-25143786
10.
Treatment with CNX-011-67, a novel GPR40 agonist, delays onset and progression of diabetes and improves beta cell preservation and function in male ZDF rats.
BMC Pharmacol Toxicol
; 14: 28, 2013 May 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-23692921
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