Detalles de la búsqueda
1.
Safety, Pharmacokinetics, and Causal Prophylactic Efficacy of KAF156 in a Plasmodium falciparum Human Infection Study.
Clin Infect Dis
; 73(7): e2407-e2414, 2021 10 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-32644127
2.
Hepatic safety and tolerability of cipargamin (KAE609), in adult patients with Plasmodium falciparum malaria: a randomized, phase II, controlled, dose-escalation trial in sub-Saharan Africa.
Malar J
; 20(1): 478, 2021 Dec 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-34930267
3.
A phase 1 evaluation of the pharmacokinetic/pharmacodynamic interaction of the anti-malarial agents KAF156 and piperaquine.
Malar J
; 17(1): 7, 2018 01 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29304859
4.
Estimation of the In Vivo MIC of Cipargamin in Uncomplicated Plasmodium falciparum Malaria.
Antimicrob Agents Chemother
; 61(2)2017 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-27872070
5.
Bioavailability of Lumefantrine Is Significantly Enhanced with a Novel Formulation Approach, an Outcome from a Randomized, Open-Label Pharmacokinetic Study in Healthy Volunteers.
Antimicrob Agents Chemother
; 61(9)2017 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28630183
6.
Spiroindolone KAE609 for falciparum and vivax malaria.
N Engl J Med
; 371(5): 403-10, 2014 Jul 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-25075833
7.
KAE609 (Cipargamin), a New Spiroindolone Agent for the Treatment of Malaria: Evaluation of the Absorption, Distribution, Metabolism, and Excretion of a Single Oral 300-mg Dose of [14C]KAE609 in Healthy Male Subjects.
Drug Metab Dispos
; 44(5): 672-82, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26921387
8.
Open-label, single-dose, parallel-group study in healthy volunteers to determine the drug-drug interaction potential between KAE609 (cipargamin) and piperaquine.
Antimicrob Agents Chemother
; 59(6): 3493-500, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25845867
9.
Increased systemic exposures of artemether and dihydroartemisinin in infants under 5 kg with uncomplicated Plasmodium falciparum malaria treated with artemether-lumefantrine (Coartem®).
Malar J
; 14: 157, 2015 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25886021
10.
A first-in-human randomized, double-blind, placebo-controlled, single- and multiple-ascending oral dose study of novel antimalarial Spiroindolone KAE609 (Cipargamin) to assess its safety, tolerability, and pharmacokinetics in healthy adult volunteers.
Antimicrob Agents Chemother
; 58(10): 6209-14, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-25114127
11.
Evaluation of two novel tablet formulations of artemether-lumefantrine (Coartem) for bioequivalence in a randomized, open-label, two-period study.
Malar J
; 12: 312, 2013 Sep 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-24010572
12.
Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria.
J Med Chem
; 65(5): 3798-3813, 2022 03 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-35229610
13.
Amphotericin-B-loaded polymersomes formulation (PAMBO) based on (PEG)3-PLA copolymers: an in vivo evaluation in a murine model.
Mol Pharm
; 8(1): 204-12, 2011 Feb 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-21138276
14.
Self assembly of amphiphilic (PEG)(3)-PLA copolymer as polymersomes: preparation, characterization, and their evaluation as drug carrier.
Biomacromolecules
; 11(4): 1027-35, 2010 Apr 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-20178378
15.
Polyanhydrides as localized drug delivery carrier: an update.
Expert Opin Drug Deliv
; 5(8): 889-907, 2008 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-18712998
16.
Simultaneous determination of hydrazinocurcumin and phenol red in samples from rat intestinal permeability studies: HPLC method development and validation.
J Pharm Biomed Anal
; 46(2): 374-80, 2008 Jan 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-17988818
17.
Effect of sedative agent selection on morbidity, mortality and length of stay in patients with increase in intracranial pressure.
World J Emerg Med
; 9(4): 256-261, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-30181792
18.
Copolymers of pharmaceutical grade lactic acid and sebacic acid: drug release behavior and biocompatibility.
Eur J Pharm Biopharm
; 64(3): 277-86, 2006 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-16846724
19.
A Physiologically Based Pharmacokinetic Model to Describe Artemether Pharmacokinetics in Adult and Pediatric Patients.
J Pharm Sci
; 105(10): 3205-3213, 2016 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-27506269
20.
Role of polyanhydrides as localized drug carriers.
J Control Release
; 103(3): 541-63, 2005 Apr 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-15820403