Detalles de la búsqueda
1.
Treatment of Skin Inflammation with Benzoxaborole Phosphodiesterase Inhibitors: Selectivity, Cellular Activity, and Effect on Cytokines Associated with Skin Inflammation and Skin Architecture Changes.
J Pharmacol Exp Ther
; 358(3): 413-22, 2016 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27353073
2.
Crisaborole Topical Ointment, 2%: A Nonsteroidal, Topical, Anti-Inflammatory Phosphodiesterase 4 Inhibitor in Clinical Development for the Treatment of Atopic Dermatitis.
J Drugs Dermatol
; 15(4): 390-6, 2016 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-27050693
3.
Inhibition of Toll-like receptor-mediated inflammation in vitro and in vivo by a novel benzoxaborole.
J Pharmacol Exp Ther
; 344(2): 436-46, 2013 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-23192653
4.
Linking phenotype to kinase: identification of a novel benzoxaborole hinge-binding motif for kinase inhibition and development of high-potency rho kinase inhibitors.
J Pharmacol Exp Ther
; 347(3): 615-25, 2013 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-24049062
5.
Structure-activity relationships of 6-(aminomethylphenoxy)-benzoxaborole derivatives as anti-inflammatory agent.
Bioorg Med Chem Lett
; 23(6): 1680-3, 2013 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23411072
6.
Discovery and structure-activity relationships of 6-(benzoylamino)benzoxaboroles as orally active anti-inflammatory agents.
Bioorg Med Chem Lett
; 23(21): 5870-3, 2013 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24075731
7.
A precisely humanized FCRN transgenic mouse for preclinical pharmacokinetics studies.
Biochem Pharmacol
; 210: 115470, 2023 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36870576
8.
Animal models for SARS-Cov2/Covid19 research-A commentary.
Biochem Pharmacol
; 188: 114543, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33812856
9.
Discovery of novel orally bioavailable oxaborole 6-carboxamides that demonstrate cure in a murine model of late-stage central nervous system african trypanosomiasis.
Antimicrob Agents Chemother
; 54(10): 4379-88, 2010 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-20660666
10.
Macrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 1. Amide Linked Analogs.
ACS Infect Dis
; 6(2): 173-179, 2020 02 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-31876154
11.
The liver pharmacological and xenobiotic gene response repertoire.
Mol Syst Biol
; 4: 175, 2008.
Artículo
en Inglés
| MEDLINE | ID: mdl-18364709
12.
Considerations for development of therapies for cutaneous neurofibroma.
Neurology
; 91(2 Suppl 1): S21-S30, 2018 07 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29987132
13.
Clinical trial design for cutaneous neurofibromas.
Neurology
; 91(2 Suppl 1): S31-S37, 2018 07 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29987133
14.
Use of a mixed tissue RNA design for performance assessments on multiple microarray formats.
Nucleic Acids Res
; 33(22): e187, 2005 Dec 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-16377776
15.
Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target.
PLoS Negl Trop Dis
; 11(7): e0005680, 2017 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-28704396
16.
Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action.
J Biotechnol
; 119(3): 219-44, 2005 Sep 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-16005536
17.
Early rapid identification of in vivo rat metabolites of AN6414, a novel boron-containing PDE4 inhibitor by QTRAP LC/MS/MS to support drug discovery.
J Pharm Biomed Anal
; 70: 344-53, 2012 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-22687459
18.
Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center.
FEBS Lett
; 586(19): 3410-4, 2012 Sep 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-22841723
19.
Abating progressive tissue injury and preserving function after CNS trauma: The role of inflammation modulatory therapies.
Curr Opin Investig Drugs
; 11(11): 1207-10, 2010 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-21189657
20.
NSAID-induced acute phase response is due to increased intestinal permeability and characterized by early and consistent alterations in hepatic gene expression.
Toxicol Pathol
; 34(2): 168-79, 2006.
Artículo
en Inglés
| MEDLINE | ID: mdl-16642600