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1.
A small-molecule inhibitor of C5 complement protein.
Nat Chem Biol
; 15(7): 666-668, 2019 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-31209353
2.
Transaminases Provide Key Chiral Building Blocks for the Synthesis of Selective M1/M4 Agonists.
ACS Med Chem Lett
; 14(12): 1692-1699, 2023 Dec 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-38116445
3.
Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
J Med Chem
; 63(11): 5697-5722, 2020 06 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32073845
4.
Discovery of TD-0212, an Orally Active Dual Pharmacology AT1 Antagonist and Neprilysin Inhibitor (ARNI).
ACS Med Chem Lett
; 10(1): 86-91, 2019 Jan 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-30655952
5.
Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway.
J Med Chem
; 62(9): 4656-4668, 2019 05 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-30995036
6.
The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration.
J Med Chem
; 61(4): 1622-1635, 2018 02 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-29400470
7.
The versatility of alpha-chloropropargyl phenyl sulfide affords high stereo- and regioselectivities in indium-promoted coupling reactions under mild conditions.
J Org Chem
; 67(1): 136-45, 2002 Jan 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-11777451
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