Detalles de la búsqueda
1.
Aldosterone synthase inhibition: cardiorenal protection in animal disease models and translation of hormonal effects to human subjects.
J Transl Med
; 12: 340, 2014 Dec 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-25491597
2.
Pharmacodynamic and pharmacokinetic characterization of the aldosterone synthase inhibitor FAD286 in two rodent models of hyperaldosteronism: comparison with the 11beta-hydroxylase inhibitor metyrapone.
J Pharmacol Exp Ther
; 334(1): 232-43, 2010 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-20354176
3.
The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-beta-hydroxylase.
Bioorg Med Chem Lett
; 20(15): 4324-7, 2010 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20615692
4.
Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin Inhibitors.
ACS Med Chem Lett
; 11(2): 188-194, 2020 Feb 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-32071687
5.
Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors.
Anal Biochem
; 394(1): 56-61, 2009 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19622340
6.
Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: a comparison with spironolactone.
Eur Heart J
; 29(17): 2171-9, 2008 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-18586661
7.
Functional neuroprotective effect of CGS 26303, a dual ECE inhibitor, on ischemic-reperfusion spinal cord injury in rats.
Exp Biol Med (Maywood)
; 232(2): 214-8, 2007 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-17259328
8.
Attenuation of experimental subarachnoid hemorrhage-induced increases in circulating intercellular adhesion molecule-1 and cerebral vasospasm by the endothelin-converting enzyme inhibitor CGS 26303.
J Neurosurg
; 106(3): 442-8, 2007 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-17367067
9.
Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage.
Circulation
; 111(23): 3087-94, 2005 Jun 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-15939810
10.
Effects of sildenafil on pulmonary hypertension and levels of ET-1, eNOS, and cGMP in aorta-banded rats.
Exp Biol Med (Maywood)
; 231(6): 942-7, 2006 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-16741028
11.
Differential change in expression of pulmonary ET-1 and eNOS in rats after chronic left ventricular pressure overload.
Exp Biol Med (Maywood)
; 231(6): 948-53, 2006 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-16741029
12.
17beta-estradiol inhibits endothelin-1 production and attenuates cerebral vasospasm after experimental subarachnoid hemorrhage.
Exp Biol Med (Maywood)
; 231(6): 1054-7, 2006 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-16741048
13.
Prevention and reversal of vasospasm and ultrastructural changes in basilar artery by continuous infusion of CGS 35066 following subarachnoid hemorrhage.
Exp Biol Med (Maywood)
; 231(6): 1069-74, 2006 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-16741051
14.
Endothelin-converting enzyme inhibitors for the treatment of subarachnoid hemorrhage-induced vasospasm.
Neurol Res
; 28(7): 721-9, 2006 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-17164035
15.
Perhydroquinolylbenzamides as novel inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
J Med Chem
; 48(21): 6696-712, 2005 Oct 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-16220986
16.
Triple vasopeptidase inhibition normalizes blood pressure in conscious, unrestrained, and spontaneously hypertensive rats.
Am J Hypertens
; 18(12 Pt 1): 1606-13, 2005 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-16364833
17.
Structure-Activity Relationships, Pharmacokinetics, and in Vivo Activity of CYP11B2 and CYP11B1 Inhibitors.
J Med Chem
; 58(11): 4749-70, 2015 Jun 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-25953419
18.
Discovery of N-[5-(6-Chloro-3-cyano-1-methyl-1H-indol-2-yl)-pyridin-3-ylmethyl]-ethanesulfonamide, a Cortisol-Sparing CYP11B2 Inhibitor that Lowers Aldosterone in Human Subjects.
J Med Chem
; 58(23): 9382-94, 2015 Dec 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-26540564
19.
The design, structure, and clinical update of small molecular weight matrix metalloproteinase inhibitors.
Curr Med Chem
; 11(22): 2911-77, 2004 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-15544483
20.
Endothelin and subarachnoid hemorrhage-induced cerebral vasospasm: pathogenesis and treatment.
Curr Med Chem
; 11(13): 1779-91, 2004 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-15279581