Detalles de la búsqueda
1.
Intact quantitation of cysteine-conjugated antibody-drug conjugates using native mass spectrometry.
Rapid Commun Mass Spectrom
; 38(15): e9774, 2024 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38812280
2.
Broad Application of CYP3A4 Liquid Chromatography-Mass Spectrometry Protein Quantification in Hepatocyte Cytochrome P450 Induction Assays Identifies Nonuniformity in mRNA and Protein Induction Responses.
Drug Metab Dispos
; 50(2): 105-113, 2022 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34857529
3.
Use of in-sample calibration curve approach for quantification of peptides with high-resolution mass spectrometry.
Rapid Commun Mass Spectrom
; 36(22): e9377, 2022 Nov 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-35940586
4.
Quantitation of Plasma Membrane Drug Transporters in Kidney Tissue and Cell Lines Using a Novel Proteomic Approach Enabled a Prospective Prediction of Metformin Disposition.
Drug Metab Dispos
; 49(10): 938-946, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34330717
5.
Assessing the Impact of Endogenously Derived Crystalline Drug on the in Vivo Performance of Amorphous Formulations.
Mol Pharm
; 16(8): 3617-3625, 2019 08 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-31260625
6.
Mathematical and Experimental Validation of Flux Dialysis Method: An Improved Approach to Measure Unbound Fraction for Compounds with High Protein Binding and Other Challenging Properties.
Drug Metab Dispos
; 46(4): 458-469, 2018 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29437872
7.
Ubiquitination of neuronal nitric-oxide synthase in the calmodulin-binding site triggers proteasomal degradation of the protein.
J Biol Chem
; 287(51): 42601-10, 2012 Dec 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-23109339
8.
Signature peptide selection workflow for biomarker quantification using LC-MS-based targeted proteomics.
Bioanalysis
; 15(5): 295-300, 2023 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-37040396
9.
A Simplified Method for Determining Blood-to-Plasma Ratios in vitro and ex vivo by Matrix Matching with Blank Blood or Plasma.
Drug Metab Bioanal Lett
; 16(2): 113-120, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37592774
10.
Bioanalytical strategy for the characterization and bioanalysis of biologics: a global, nonregulated bioanalytical lab perspective.
Bioanalysis
; 15(3): 133-148, 2023 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-36891956
11.
Integrity and efficiency: AbbVie's journey of building an integrated nonregulated bioanalytical laboratory.
Bioanalysis
; 15(3): 161-176, 2023 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-36961367
12.
Identification of Plasma Biomarkers from Rheumatoid Arthritis Patients Using an Optimized Sequential Window Acquisition of All THeoretical Mass Spectra (SWATH) Proteomics Workflow.
Proteomes
; 11(4)2023 Oct 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-37873874
13.
Expanding the Repertoire for "Large Small Molecules": Prodrug ABBV-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers.
Mol Cancer Ther
; 20(6): 999-1008, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33785651
14.
Effects of microtubule-inhibiting small molecule and antibody-drug conjugate treatment on differentially-sized A431 squamous carcinoma spheroids.
Sci Rep
; 10(1): 907, 2020 01 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-31969631
15.
Amorphous solid dispersions of enzalutamide and novel polysaccharide derivatives: investigation of relationships between polymer structure and performance.
Sci Rep
; 10(1): 18535, 2020 10 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-33116200
16.
Determination of IL-23 Pharmacokinetics by Highly Sensitive Accelerator Mass Spectrometry and Subsequent Modeling to Project IL-23 Suppression in Psoriasis Patients Treated with Anti-IL-23 Antibodies.
AAPS J
; 21(5): 82, 2019 06 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-31250228
17.
Introducing the 2023 Bioanalysis special-themed issue on laboratory structure and management for nonregulated bioanalysis.
Bioanalysis
; 15(3): 99-101, 2023 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-36994780
18.
Towards in vitro models for reducing or replacing the use of animals in drug testing.
Nat Biomed Eng
; 2023 Dec 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-38151640
19.
High-Throughput, Multispecies, Parallelized Plasma Stability Assay for the Determination and Characterization of Antibody-Drug Conjugate Aggregation and Drug Release.
ACS Omega
; 2(8): 4207-4215, 2017 Aug 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-30023717
20.
Tetrahydrobiopterin depletion and ubiquitylation of neuronal nitric oxide synthase.
Brain Res Mol Brain Res
; 142(1): 19-27, 2005 Dec 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-16216381