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1.
Allosteric inhibitors of hepatitis C polymerase: discovery of potent and orally bioavailable carbon-linked dihydropyrones.
J Med Chem
; 50(17): 3969-72, 2007 Aug 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-17658778
2.
Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. Identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide.
J Med Chem
; 54(9): 3368-85, 2011 May 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-21438541
3.
Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor.
J Med Chem
; 52(5): 1255-8, 2009 Mar 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-19209845
4.
Identification and structure-based optimization of novel dihydropyrones as potent HCV RNA polymerase inhibitors.
Bioorg Med Chem Lett
; 16(18): 4834-8, 2006 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16824756
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