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1.
TLR7 tolerance is independent of the type I IFN pathway and leads to loss of anti-tumor efficacy in mice.
Cancer Immunol Immunother
; 64(10): 1229-39, 2015 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-26091797
2.
A novel systemically administered Toll-like receptor 7 agonist potentiates the effect of ionizing radiation in murine solid tumor models.
Int J Cancer
; 135(4): 820-9, 2014 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24390981
3.
Biomarker-directed targeted therapy plus durvalumab in advanced non-small-cell lung cancer: a phase 2 umbrella trial.
Nat Med
; 30(3): 716-729, 2024 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-38351187
4.
Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase with Application as an Anticancer Agent.
J Med Chem
; 61(22): 9889-9907, 2018 11 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-30346772
5.
Dissecting the determinants of cyclin-dependent kinase 2 and cyclin-dependent kinase 4 inhibitor selectivity.
J Med Chem
; 49(18): 5470-7, 2006 Sep 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-16942020
6.
Intravenous administration of the selective toll-like receptor 7 agonist DSR-29133 leads to anti-tumor efficacy in murine solid tumor models which can be potentiated by combination with fractionated radiotherapy.
Oncotarget
; 7(13): 17035-46, 2016 Mar 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-26959743
7.
Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo.
Sci Transl Med
; 8(325): 325ra17, 2016 Feb 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-26865565
8.
N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2.
J Med Chem
; 47(15): 3710-22, 2004 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-15239650
9.
Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives.
J Med Chem
; 45(16): 3381-93, 2002 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-12139449
10.
8-Substituted O(6)-cyclohexylmethylguanine CDK2 inhibitors: using structure-based inhibitor design to optimize an alternative binding mode.
J Med Chem
; 57(1): 56-70, 2014 Jan 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-24304238
11.
Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity.
J Med Chem
; 56(5): 2125-38, 2013 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-23394205
12.
REPLACE: a strategy for iterative design of cyclin-binding groove inhibitors.
Chembiochem
; 7(12): 1909-15, 2006 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-17051658
13.
FDS: flexible ligand and receptor docking with a continuum solvent model and soft-core energy function.
J Comput Chem
; 24(13): 1637-56, 2003 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-12926007
14.
Novel, potent and selective anilinoquinazoline and anilinopyrimidine inhibitors of p38 MAP kinase.
Bioorg Med Chem Lett
; 14(21): 5389-94, 2004 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15454232
15.
Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 1: identification and optimisation of substituted 4,6-bis anilino pyrimidines.
Bioorg Med Chem Lett
; 13(18): 2955-60, 2003 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-12941311
16.
Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 2: identification and optimisation of substituted 2,4-bis anilino pyrimidines.
Bioorg Med Chem Lett
; 13(18): 2961-6, 2003 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-12941312
17.
Imidazo[1,2-a]pyridines: a potent and selective class of cyclin-dependent kinase inhibitors identified through structure-based hybridisation.
Bioorg Med Chem Lett
; 13(18): 3021-6, 2003 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-12941325
18.
Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2.
Bioorg Med Chem Lett
; 13(18): 3079-82, 2003 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-12941338
19.
Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor.
Nat Struct Biol
; 9(10): 745-9, 2002 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-12244298
20.
4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2.
Bioorg Med Chem Lett
; 13(2): 217-22, 2003 Jan 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-12482427
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