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1.
PolyQ-expanded ataxin-2 aggregation impairs cellular processing-body homeostasis via sequestering the RNA helicase DDX6.
J Biol Chem
; : 107413, 2024 May 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-38810698
2.
PABPN1 aggregation is driven by Ala expansion and poly(A)-RNA binding, leading to CFIm25 sequestration that impairs alternative polyadenylation.
J Biol Chem
; 299(8): 105019, 2023 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-37422193
3.
RNA-assisted sequestration of RNA-binding proteins by cytoplasmic inclusions of the C-terminal 35-kDa fragment of TDP-43.
J Cell Sci
; 135(6)2022 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35142363
4.
O-GlcNAcylation of TDP-43 suppresses proteinopathies and promotes TDP-43's mRNA splicing activity.
EMBO Rep
; 22(6): e51649, 2021 06 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33855783
5.
Coaggregation of polyglutamine (polyQ) proteins is mediated by polyQ-tract interactions and impairs cellular proteostasis.
Acta Biochim Biophys Sin (Shanghai)
; 55(5): 736-748, 2023 May 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-37171184
6.
Domain interactions reveal auto-inhibition of the deubiquitinating enzyme USP19 and its activation by HSP90 in the modulation of huntingtin aggregation.
Biochem J
; 477(21): 4295-4312, 2020 11 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-33094816
7.
Solid-State NMR Reveals the Structural Transformation of the TDP-43 Amyloidogenic Region upon Fibrillation.
J Am Chem Soc
; 142(7): 3412-3421, 2020 02 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-32003979
8.
PolyQ-expanded huntingtin and ataxin-3 sequester ubiquitin adaptors hHR23B and UBQLN2 into aggregates via conjugated ubiquitin.
FASEB J
; 32(6): 2923-2933, 2018 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-29401586
9.
Aggregation of Polyglutamine-expanded Ataxin 7 Protein Specifically Sequesters Ubiquitin-specific Protease 22 and Deteriorates Its Deubiquitinating Function in the Spt-Ada-Gcn5-Acetyltransferase (SAGA) Complex.
J Biol Chem
; 290(36): 21996-2004, 2015 Sep 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-26195632
10.
Structural transformation of the amyloidogenic core region of TDP-43 protein initiates its aggregation and cytoplasmic inclusion.
J Biol Chem
; 288(27): 19614-24, 2013 Jul 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-23689371
11.
Ataxin-2 sequesters Raptor into aggregates and impairs cellular mTORC1 signaling.
FEBS J
; 291(8): 1795-1812, 2024 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-38308810
12.
Aggregation of the 35-kDa fragment of TDP-43 causes formation of cytoplasmic inclusions and alteration of RNA processing.
FASEB J
; 25(7): 2344-53, 2011 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-21450909
13.
PolyQ-expanded proteins impair cellular proteostasis of ataxin-3 through sequestering the co-chaperone HSJ1 into aggregates.
Sci Rep
; 11(1): 7815, 2021 04 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-33837238
14.
Author Correction: Structural and dynamic studies reveal that the Ala-rich region of ataxin-7 initiates α-helix formation of the polyQ tract but suppresses its aggregation.
Sci Rep
; 10(1): 9519, 2020 Jun 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32518289
15.
Structural and dynamic studies reveal that the Ala-rich region of ataxin-7 initiates α-helix formation of the polyQ tract but suppresses its aggregation.
Sci Rep
; 9(1): 7481, 2019 05 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-31097749
16.
Study of Protein Amyloid-Like Aggregates by Solid-State Circular Dichroism Spectroscopy.
Curr Protein Pept Sci
; 18(1): 100-103, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-27396751
17.
HSP90 recognizes the N-terminus of huntingtin involved in regulation of huntingtin aggregation by USP19.
Sci Rep
; 7(1): 14797, 2017 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29093475
18.
The N-terminal dimerization is required for TDP-43 splicing activity.
Sci Rep
; 7(1): 6196, 2017 07 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-28733604
19.
Two mutations G335D and Q343R within the amyloidogenic core region of TDP-43 influence its aggregation and inclusion formation.
Sci Rep
; 6: 23928, 2016 Mar 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-27030292
20.
TDP-35 sequesters TDP-43 into cytoplasmic inclusions through binding with RNA.
FEBS Lett
; 589(15): 1920-8, 2015 Jul 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-26099433
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