Detalles de la búsqueda
1.
Discovery of low-molecular-weight phenylalanine derivatives as novel HIV capsid modulators with improved antiretroviral activity and metabolic stability.
J Med Virol
; 96(4): e29594, 2024 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-38576317
2.
Discovery of novel 1,2,4-triazole phenylalanine derivatives targeting an unexplored region within the interprotomer pocket of the HIV capsid protein.
J Med Virol
; 94(12): 5975-5986, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-35949003
3.
Design, synthesis, and biological evaluation of novel sulfamoylbenzamide derivatives as HBV capsid assembly modulators.
Bioorg Chem
; 129: 106192, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-36265355
4.
Discovery and Mechanistic Investigation of Piperazinone Phenylalanine Derivatives with Terminal Indole or Benzene Ring as Novel HIV-1 Capsid Modulators.
Molecules
; 27(23)2022 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36500508
5.
Design, Synthesis, and Mechanistic Study of 2-Pyridone-Bearing Phenylalanine Derivatives as Novel HIV Capsid Modulators.
Molecules
; 27(21)2022 Nov 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-36364467
6.
Design, Synthesis, and Evaluation of a Set of Carboxylic Acid and Phosphate Prodrugs Derived from HBV Capsid Protein Allosteric Modulator NVR 3-778.
Molecules
; 27(18)2022 Sep 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-36144715
7.
Design, Synthesis and Structure-Activity Relationships of Phenylalanine-Containing Peptidomimetics as Novel HIV-1 Capsid Binders Based on Ugi Four-Component Reaction.
Molecules
; 27(18)2022 Sep 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-36144727
8.
Design, synthesis, and antiviral activity of phenylalanine derivatives as HIV-1 capsid inhibitors.
Bioorg Med Chem
; 48: 116414, 2021 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34562701
9.
Molecular design opportunities presented by solvent-exposed regions of target proteins.
Med Res Rev
; 39(6): 2194-2238, 2019 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31002405
10.
Advances in drug structure-activity-relationships for the development of selenium-based compounds against HIV.
Expert Opin Drug Discov
; 19(2): 139-146, 2024 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-37988053
11.
The discovery and design of novel HIV-1 capsid modulators and future perspectives.
Expert Opin Drug Discov
; 18(1): 5-12, 2023 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36480372
12.
Design, synthesis, and mechanistic study of 2-piperazineone-bearing peptidomimetics as novel HIV capsid modulators.
RSC Med Chem
; 14(7): 1272-1295, 2023 Jul 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-37484571
13.
Discovery of novel diarypyrimidine derivatives bearing six-membered non-aromatic heterocycles as potent HIV-1 NNRTIs with improved anti-resistance and drug-like profiles.
Eur J Med Chem
; 258: 115605, 2023 Oct 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37393790
14.
Identification of novel 1,2,3-triazole isatin derivatives as potent SARS-CoV-2 3CLpro inhibitors via click-chemistry-based rapid screening.
RSC Med Chem
; 14(10): 2068-2078, 2023 Oct 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-37859715
15.
Discovery, Crystallographic Studies, and Mechanistic Investigations of Novel Phenylalanine Derivatives Bearing a Quinazolin-4-one Scaffold as Potent HIV Capsid Modulators.
J Med Chem
; 66(23): 16303-16329, 2023 12 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-38054267
16.
Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors.
Commun Chem
; 6(1): 83, 2023 Apr 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-37120482
17.
Contemporary Medicinal Chemistry Strategies for the Discovery and Development of Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors.
J Med Chem
; 65(5): 3729-3757, 2022 03 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-35175760
18.
The current progress in the use of boron as a platform for novel antiviral drug design.
Expert Opin Drug Discov
; 17(12): 1329-1340, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-36448326
19.
Development of Novel Dihydrofuro[3,4-d]pyrimidine Derivatives as HIV-1 NNRTIs to Overcome the Highly Resistant Mutant Strains F227L/V106A and K103N/Y181C.
J Med Chem
; 65(3): 2458-2470, 2022 02 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-35061384
20.
Design, synthesis, and mechanistic investigations of phenylalanine derivatives containing a benzothiazole moiety as HIV-1 capsid inhibitors with improved metabolic stability.
Eur J Med Chem
; 227: 113903, 2022 Jan 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-34653770