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1.
Pharmacologically inhibiting phosphoglycerate kinase 1 for glioma with NG52.
Acta Pharmacol Sin
; 42(4): 633-640, 2021 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-32737469
2.
Osimertinib successfully combats EGFR-negative glioblastoma cells by inhibiting the MAPK pathway.
Acta Pharmacol Sin
; 42(1): 108-114, 2021 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-32398685
3.
Discovery of a novel and highly selective CDK9 kinase inhibitor (JSH-009) with potent antitumor efficacy in preclinical acute myeloid leukemia models.
Invest New Drugs
; 38(5): 1272-1281, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31872348
4.
[Construction and Identification of Transgenic Strain of Toxoplasma gondii High-expressing Virulence Factor ROP18].
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi
; 33(1): 14-8, 2015 Feb.
Artículo
en Zh
| MEDLINE | ID: mdl-26080519
5.
Discovery of IHMT-337 as a potent irreversible EZH2 inhibitor targeting CDK4 transcription for malignancies.
Signal Transduct Target Ther
; 8(1): 18, 2023 01 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-36642705
6.
Discovery of a highly potent pan-RAF inhibitor IHMT-RAF-128 for cancer treatment.
Eur J Pharmacol
; 952: 175752, 2023 Aug 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37164118
7.
Nintedanib overcomes drug resistance from upregulation of FGFR signalling and imatinib-induced KIT mutations in gastrointestinal stromal tumours.
Mol Oncol
; 16(8): 1761-1774, 2022 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-35194937
8.
Inhibition of the deubiquitinating enzyme USP47 as a novel targeted therapy for hematologic malignancies expressing mutant EZH2.
Leukemia
; 36(4): 1048-1057, 2022 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-35034955
9.
Discovery of IHMT-EZH2-115 as a Potent and Selective Enhancer of Zeste Homolog 2 (EZH2) Inhibitor for the Treatment of B-Cell Lymphomas.
J Med Chem
; 64(20): 15170-15188, 2021 10 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-34664960
10.
All-trans retinoic acid exerts selective anti-FLT3-ITD acute myeloid leukemia efficacy through downregulating Chk1 kinase.
Cancer Lett
; 473: 130-138, 2020 03 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-31904486
11.
Discovery of 6'-chloro-N-methyl-5'-(phenylsulfonamido)-[3,3'-bipyridine]-5-carboxamide (CHMFL-PI4K-127) as a novel Plasmodium falciparum PI(4)K inhibitor with potent antimalarial activity against both blood and liver stages of Plasmodium.
Eur J Med Chem
; 188: 112012, 2020 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31911293
12.
Discovery of a highly selective VEGFR2 kinase inhibitor CHMFL-VEGFR2-002 as a novel anti-angiogenesis agent.
Acta Pharm Sin B
; 10(3): 488-497, 2020 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-32140394
13.
Discovery of (E)-N-(4-methyl-5-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thiazol-2-yl)-2-(4-methylpiperazin-1-yl)acetamide (IHMT-TRK-284) as a novel orally available type II TRK kinase inhibitor capable of overcoming multiple resistant mutants.
Eur J Med Chem
; 207: 112744, 2020 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32949955
14.
Discovery of (S)-2-(1-(4-Amino-3-(3-fluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)propyl)-3-cyclopropyl-5-fluoroquinazolin-4(3H)-one (IHMT-PI3Kδ-372) as a Potent and Selective PI3Kδ Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease.
J Med Chem
; 63(22): 13973-13993, 2020 11 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-33180507
15.
Discovery of ( E)- N1-(3-Fluorophenyl)- N3-(3-(2-(pyridin-2-yl)vinyl)-1 H-indazol-6-yl)malonamide (CHMFL-KIT-033) as a Novel c-KIT T670I Mutant Selective Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs).
J Med Chem
; 62(10): 5006-5024, 2019 05 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-31046271
16.
Repurposing cabozantinib to GISTs: Overcoming multiple imatinib-resistant cKIT mutations including gatekeeper and activation loop mutants in GISTs preclinical models.
Cancer Lett
; 447: 105-114, 2019 04 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-30684595
17.
Pharmacological inhibiting STAT5 for the treatment of FLT3-ITD-positive acute myeloid leukemia with triciribine phosphate monohydrate.
MedComm (2020)
; 4(4): e294, 2023 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-37361897
18.
Discovery of (S)-2-amino-N-(5-(6-chloro-5-(3-methylphenylsulfonamido)pyridin-3-yl)-4-methylthiazol-2-yl)-3-methylbutanamide (CHMFL-PI3KD-317) as a potent and selective phosphoinositide 3-kinase delta (PI3Kδ) inhibitor.
Eur J Med Chem
; 156: 831-846, 2018 Aug 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30053721
19.
Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino)cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor.
Eur J Med Chem
; 158: 896-916, 2018 Oct 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30253346
20.
Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia.
Eur J Med Chem
; 160: 61-81, 2018 Dec 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30317026