Detalles de la búsqueda
1.
Structure of the Respiratory Syncytial Virus Polymerase Complex.
Cell
; 179(1): 193-204.e14, 2019 Sep 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-31495574
2.
Synthesis and Anti-Hepatitis B Activities of 3'-Fluoro-2'-Substituted Apionucleosides.
Molecules
; 27(8)2022 Apr 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35458620
3.
Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate.
PLoS Pathog
; 11(6): e1004995, 2015 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-26098424
4.
Subgenomic promoter recognition by the norovirus RNA-dependent RNA polymerases.
Nucleic Acids Res
; 43(1): 446-60, 2015 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-25520198
5.
NTP-mediated nucleotide excision activity of hepatitis C virus RNA-dependent RNA polymerase.
Proc Natl Acad Sci U S A
; 110(5): E348-57, 2013 Jan 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-23307808
6.
Biochemical Evaluation of the Inhibition Properties of Favipiravir and 2'-C-Methyl-Cytidine Triphosphates against Human and Mouse Norovirus RNA Polymerases.
Antimicrob Agents Chemother
; 59(12): 7504-16, 2015 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26392512
7.
Efficiency of incorporation and chain termination determines the inhibition potency of 2'-modified nucleotide analogs against hepatitis C virus polymerase.
Antimicrob Agents Chemother
; 58(7): 3636-45, 2014 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-24733478
8.
JNJ-7184, a respiratory syncytial virus inhibitor targeting the connector domain of the viral polymerase.
Antiviral Res
; 227: 105907, 2024 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-38772503
9.
Assembly, purification, and pre-steady-state kinetic analysis of active RNA-dependent RNA polymerase elongation complex.
J Biol Chem
; 287(13): 10674-10683, 2012 Mar 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-22303022
10.
Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor.
Commun Biol
; 6(1): 1074, 2023 10 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-37865687
11.
Role of a GAG hinge in the nucleotide-induced conformational change governing nucleotide specificity by T7 DNA polymerase.
J Biol Chem
; 286(2): 1312-22, 2011 Jan 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-20978284
12.
Characterization of the elongation complex of dengue virus RNA polymerase: assembly, kinetics of nucleotide incorporation, and fidelity.
J Biol Chem
; 286(3): 2067-77, 2011 Jan 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-21078673
13.
Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of AL-611 as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis C.
J Med Chem
; 63(18): 10380-10395, 2020 09 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-32816483
14.
Pre-steady-state kinetic analysis of cis-3-chloroacrylic acid dehalogenase: analysis and implications.
Biochemistry
; 48(49): 11737-44, 2009 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19856961
15.
Site-specific labeling of T7 DNA polymerase with a conformationally sensitive fluorophore and its use in detecting single-nucleotide polymorphisms.
Anal Biochem
; 384(1): 136-44, 2009 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18834851
16.
Synthesis and Anti-HCV Activities of 4'-Fluoro-2'-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4'-Fluoro-2'- C-methyluridine 5'-Phosphoramidate Prodrug (AL-335) for the Treatment of Hepatitis C Infection.
J Med Chem
; 62(9): 4555-4570, 2019 05 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-30951311
17.
Structure(s), function(s), and inhibition of the RNA-dependent RNA polymerase of noroviruses.
Virus Res
; 234: 21-33, 2017 04 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28041960
18.
Structure-activity relationship analysis of mitochondrial toxicity caused by antiviral ribonucleoside analogs.
Antiviral Res
; 143: 151-161, 2017 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-28412183
19.
Synthesis and Anti-Influenza Activity of Pyridine, Pyridazine, and Pyrimidine C-Nucleosides as Favipiravir (T-705) Analogues.
J Med Chem
; 59(10): 4611-24, 2016 05 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-27120583
20.
Discovery of 4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine (ALS-8176), a first-in-class RSV polymerase inhibitor for treatment of human respiratory syncytial virus infection.
J Med Chem
; 58(4): 1862-78, 2015 Feb 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-25667954