Detalles de la búsqueda
1.
Tritium and deuterium labelling of a kainate receptor antagonist and evaluation as a radioligand.
J Labelled Comp Radiopharm
; 67(4): 120-130, 2024 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-38332677
2.
Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype.
Int J Mol Sci
; 23(15)2022 Aug 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35955932
3.
Design, synthesis and structure-activity relationships of novel phenylalanine-based amino acids as kainate receptors ligands.
Bioorg Med Chem Lett
; 26(22): 5568-5572, 2016 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27765511
4.
Design, synthesis and in vitro pharmacology of GluK1 and GluK3 antagonists. Studies towards the design of subtype-selective antagonists through 2-carboxyethyl-phenylalanines with substituents interacting with non-conserved residues in the GluK binding sites.
Bioorg Med Chem
; 22(19): 5368-77, 2014 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25172149
5.
Structure-Activity Relationship and Solubility Studies of N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists.
ChemMedChem
; 18(18): e202300278, 2023 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37387321
6.
Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds.
J Med Chem
; 64(8): 4623-4661, 2021 04 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-33818106
7.
3-Substituted phenylalanines as selective AMPA- and kainate receptor ligands.
Bioorg Med Chem
; 17(17): 6390-401, 2009 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19656686
8.
N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists: X-ray Crystallography, Structure-Affinity Relationships, and in Vitro Pharmacology.
ACS Chem Neurosci
; 10(3): 1841-1853, 2019 03 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-30620174
9.
N-(7-(1H-Imidazol-1-yl)-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl)benzamide, a New Kainate Receptor Selective Antagonist and Analgesic: Synthesis, X-ray Crystallography, Structure-Affinity Relationships, and in Vitro and in Vivo Pharmacology.
ACS Chem Neurosci
; 10(11): 4685-4695, 2019 11 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-31622082
10.
Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency.
J Med Chem
; 51(5): 1459-63, 2008 Mar 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-18269227
11.
Bioactivation of diclofenac in vitro and in vivo: correlation to electrochemical studies.
Chem Res Toxicol
; 21(5): 1107-19, 2008 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-18419141
12.
Functional characterization of Tet-AMPA [tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic acid] analogues at ionotropic glutamate receptors GluR1-GluR4. The molecular basis for the functional selectivity profile of 2-Bn-Tet-AMPA.
J Med Chem
; 50(17): 4177-85, 2007 Aug 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-17672447
13.
A tetrazolyl-substituted subtype-selective AMPA receptor agonist.
J Med Chem
; 50(10): 2408-14, 2007 May 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-17455929
14.
Aryl- and heteroaryl-substituted phenylalanines as AMPA receptor ligands.
Chem Biol Drug Des
; 90(6): 1271-1281, 2017 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-28636281
15.
Pharmacological characterization and binding modes of novel racemic and optically active phenylalanine-based antagonists of AMPA receptors.
Eur J Med Chem
; 138: 874-883, 2017 Sep 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-28738307
16.
Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and pharmacological characterization of gamma-aminobutyric acid (GABA) related compounds.
J Med Chem
; 49(14): 4442-6, 2006 Jul 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-16821803
17.
Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors.
J Med Chem
; 59(1): 448-61, 2016 Jan 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-26653877
18.
Convergent synthesis and pharmacology of substituted tetrazolyl-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid analogues.
J Med Chem
; 48(9): 3438-42, 2005 May 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-15857151
19.
Structural and pharmacological characterization of phenylalanine-based AMPA receptor antagonists at kainate receptors.
ChemMedChem
; 7(10): 1793-8, 2012 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-22407805
20.
A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure: synthesis, resolution, pharmacology, and crystal structure.
J Med Chem
; 54(20): 7289-98, 2011 Oct 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-21923187