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1.
Novel fusion of GLP-1 with a domain antibody to serum albumin prolongs protection against myocardial ischemia/reperfusion injury in the rat.
Cardiovasc Diabetol
; 12: 148, 2013 Oct 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-24125539
2.
Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase.
Bioorg Med Chem Lett
; 23(12): 3584-8, 2013 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23664879
3.
Development of an LC-MS/MS assay for quantification of intact INSL3 in rat plasma.
Bioanalysis
; 15(19): 1169-1178, 2023 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-37676652
4.
Design and Optimization of an Acyclic Amine Series of TRPV4 Antagonists by Electronic Modulation of Hydrogen Bond Interactions.
J Med Chem
; 63(23): 14867-14884, 2020 12 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-33201708
5.
Discovery of GSK3527497: A Candidate for the Inhibition of Transient Receptor Potential Vanilloid-4 (TRPV4).
J Med Chem
; 62(20): 9270-9280, 2019 10 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-31532662
6.
4,6-Diaminopyrimidines as Highly Preferred Troponin I-Interacting Kinase (TNNI3K) Inhibitors.
J Med Chem
; 61(7): 3076-3088, 2018 04 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29561151
7.
Design and Optimization of Sulfone Pyrrolidine Sulfonamide Antagonists of Transient Receptor Potential Vanilloid-4 with in Vivo Activity in a Pulmonary Edema Model.
J Med Chem
; 61(24): 11209-11220, 2018 12 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-30500190
8.
Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors.
J Med Chem
; 50(1): 6-9, 2007 Jan 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-17201405
9.
Discovery of aminofurazan-azabenzimidazoles as inhibitors of Rho-kinase with high kinase selectivity and antihypertensive activity.
J Med Chem
; 50(1): 2-5, 2007 Jan 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-17201404
10.
Investigation of the utility of published in vitro intrinsic clearance data for prediction of in vivo clearance.
J Pharmacol Toxicol Methods
; 53(2): 106-16, 2006.
Artículo
en Inglés
| MEDLINE | ID: mdl-16188462
11.
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
J Pharm Sci
; 94(7): 1467-83, 2005 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-15920768
12.
Comparison of soluble guanylate cyclase stimulators and activators in models of cardiovascular disease associated with oxidative stress.
Front Pharmacol
; 3: 128, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-22783192
13.
Cassette dosing for pharmacokinetic screening in drug discovery: comparison of clearance, volume of distribution, half-life, mean residence time, and oral bioavailability obtained by cassette and discrete dosing in rats.
J Pharm Sci
; 100(9): 3862-74, 2011 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-21360708
14.
Potent, selective and orally bioavailable dihydropyrimidine inhibitors of Rho kinase (ROCK1) as potential therapeutic agents for cardiovascular diseases.
J Med Chem
; 51(21): 6631-4, 2008 Nov 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-18842034
15.
Methods for predicting human drug metabolism.
Adv Clin Chem
; 43: 131-76, 2007.
Artículo
en Inglés
| MEDLINE | ID: mdl-17249383
16.
Extrapolation of preclinical pharmacokinetics and molecular feature analysis of "discovery-like" molecules to predict human pharmacokinetics.
Drug Metab Dispos
; 34(7): 1255-65, 2006 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-16621936
17.
Computational and experimental studies on the distribution of addition and substitution products of the microsomal glutathione transferase 1-catalyzed conjugation of glutathione with fluoroalkenes.
Chem Res Toxicol
; 16(2): 137-44, 2003 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-12588184
18.
Structure-activity relationship for the biotransformation of haloalkenes by rat liver microsomal glutathione transferase 1.
Chem Res Toxicol
; 15(8): 1036-41, 2002 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-12184787
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