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1.
Carboxypeptidase D is the only enzyme responsible for antibody C-terminal lysine cleavage in Chinese hamster ovary (CHO) cells.
Biotechnol Bioeng
; 113(10): 2100-6, 2016 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-26989081
2.
Industry view on the relative importance of "clonality" of biopharmaceutical-producing cell lines.
Biologicals
; 44(2): 117-22, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-26852257
3.
Controlling glycation of recombinant antibody in fed-batch cell cultures.
Biotechnol Bioeng
; 108(11): 2600-10, 2011 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-21618472
4.
Development of a targeted integration Chinese hamster ovary host directly targeting either one or two vectors simultaneously to a single locus using the Cre/Lox recombinase-mediated cassette exchange system.
Biotechnol Prog
; 37(4): e3140, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33666334
5.
Mechanisms of unintended amino acid sequence changes in recombinant monoclonal antibodies expressed in Chinese Hamster Ovary (CHO) cells.
Biotechnol Bioeng
; 107(1): 163-71, 2010 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20506532
6.
Development and characterization of an automated imaging workflow to generate clonally-derived cell lines for therapeutic proteins.
Biotechnol Prog
; 34(3): 584-592, 2018 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28960825
7.
A strategy to accelerate protein production from a pool of clones in Chinese hamster ovary cells for toxicology studies.
Biotechnol Prog
; 33(6): 1449-1455, 2017 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28371489
8.
Effects of copper on CHO cells: cellular requirements and product quality considerations.
Biotechnol Prog
; 31(1): 226-38, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25311542
9.
Complete knockout of the lactate dehydrogenase A gene is lethal in pyruvate dehydrogenase kinase 1, 2, 3 down-regulated CHO cells.
Mol Biotechnol
; 56(9): 833-8, 2014 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-24841241
10.
Fast identification of reliable hosts for targeted cell line development from a limited-genome screening using combined φC31 integrase and CRE-Lox technologies.
Biotechnol Prog
; 29(5): 1307-15, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-23926028
11.
Chinese hamster ovary K1 host cell enables stable cell line development for antibody molecules which are difficult to express in DUXB11-derived dihydrofolate reductase deficient host cell.
Biotechnol Prog
; 29(4): 980-5, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-23606666
12.
Decreasing lactate level and increasing antibody production in Chinese Hamster Ovary cells (CHO) by reducing the expression of lactate dehydrogenase and pyruvate dehydrogenase kinases.
J Biotechnol
; 153(1-2): 27-34, 2011 Apr 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-21392546
13.
Proteomic profiling of recombinant Escherichia coli in high-cell-density fermentations for improved production of an antibody fragment biopharmaceutical.
Appl Environ Microbiol
; 71(4): 1717-28, 2005 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-15811994
14.
High-level accumulation of a recombinant antibody fragment in the periplasm of Escherichia coli requires a triple-mutant (degP prc spr) host strain.
Biotechnol Bioeng
; 85(5): 463-74, 2004 Mar 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-14760686
15.
The cryptic ushA gene (ushA(c)) in natural isolates of Salmonella enterica (serotype Typhimurium) has been inactivated by a single missense mutation.
Microbiology (Reading)
; 147(Pt 7): 1887-1896, 2001 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-11429465
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