Detalles de la búsqueda
1.
Prolonged culture of human pancreatic islets under glucotoxic conditions changes their acute beta cell calcium and insulin secretion glucose response curves from sigmoid to bell-shaped.
Diabetologia
; 66(4): 709-723, 2023 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36459178
2.
Transcriptome analysis of islets from diabetes-resistant and diabetes-prone obese mice reveals novel gene regulatory networks involved in beta-cell compensation and failure.
FASEB J
; 35(6): e21608, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33977593
3.
The lack of functional nicotinamide nucleotide transhydrogenase only moderately contributes to the impairment of glucose tolerance and glucose-stimulated insulin secretion in C57BL/6J vs C57BL/6N mice.
Diabetologia
; 64(11): 2550-2561, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34448880
4.
Pancreatic ß-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes.
Nucleic Acids Res
; 46(19): 10302-10318, 2018 11 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30247717
5.
Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans.
Diabetologia
; 62(12): 2273-2286, 2019 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31624901
6.
Unveiling a common mechanism of apoptosis in ß-cells and neurons in Friedreich's ataxia.
Hum Mol Genet
; 24(8): 2274-86, 2015 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25552656
7.
Hypoxia reduces ER-to-Golgi protein trafficking and increases cell death by inhibiting the adaptive unfolded protein response in mouse beta cells.
Diabetologia
; 59(7): 1492-1502, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-27039902
8.
Glucokinase activation is beneficial or toxic to cultured rat pancreatic islets depending on the prevailing glucose concentration.
Am J Physiol Endocrinol Metab
; 309(7): E632-9, 2015 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26264555
9.
Acute nutrient regulation of the mitochondrial glutathione redox state in pancreatic ß-cells.
Biochem J
; 460(3): 411-23, 2014 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24678915
10.
Dynamic measurements of mitochondrial hydrogen peroxide concentration and glutathione redox state in rat pancreatic ß-cells using ratiometric fluorescent proteins: confounding effects of pH with HyPer but not roGFP1.
Biochem J
; 441(3): 971-8, 2012 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22050124
11.
In depth functional characterization of human induced pluripotent stem cell-derived beta cells in vitro and in vivo.
Front Cell Dev Biol
; 10: 967765, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36060810
12.
Role of activating transcription factor 3 in low glucose- and thapsigargin-induced apoptosis in cultured mouse islets.
Biochem Biophys Res Commun
; 415(2): 294-9, 2011 Nov 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-22033410
13.
Emerging Roles of Metallothioneins in Beta Cell Pathophysiology: Beyond and Above Metal Homeostasis and Antioxidant Response.
Biology (Basel)
; 10(3)2021 Feb 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-33652748
14.
Endoplasmic reticulum accumulation of Kir6.2 without activation of ER stress response in islet cells from adult Sur1 knockout mice.
Cell Tissue Res
; 340(2): 335-46, 2010 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-20383647
15.
Nutrient Metabolism, Subcellular Redox State, and Oxidative Stress in Pancreatic Islets and ß-Cells.
J Mol Biol
; 432(5): 1461-1493, 2020 03 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-31634466
16.
Aspalathin Protects Insulin-Producing ß Cells against Glucotoxicity and Oxidative Stress-Induced Cell Death.
Mol Nutr Food Res
; 64(8): e1901009, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32012427
17.
Exenatide induces frataxin expression and improves mitochondrial function in Friedreich ataxia.
JCI Insight
; 5(2)2020 01 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-31877117
18.
Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide.
Sci Transl Med
; 12(564)2020 10 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33028705
19.
Glucose Acutely Reduces Cytosolic and Mitochondrial H2O2 in Rat Pancreatic Beta Cells.
Antioxid Redox Signal
; 30(3): 297-313, 2019 01 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-29756464
20.
Phlda3 regulates beta cell survival during stress.
Sci Rep
; 9(1): 12827, 2019 09 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-31492921