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1.
Chemical screening by time-resolved X-ray scattering to discover allosteric probes.
Nat Chem Biol
; 2024 Apr 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-38671223
2.
Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity.
Nucleic Acids Res
; 51(18): 9920-9937, 2023 Oct 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-37665033
3.
Analysis of Plant-Plant Interactions Reveals the Presence of Potent Antileukemic Compounds.
Molecules
; 27(9)2022 May 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-35566279
4.
Synthesis, Crystallography, and Anti-Leukemic Activity of the Amino Adducts of Dehydroleucodine.
Molecules
; 25(20)2020 Oct 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-33092263
5.
Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells.
J Nat Prod
; 79(4): 691-6, 2016 Apr 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-27057812
6.
Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: Evaluation of potency and selectivity derived from distinct binding pockets.
Bioorg Med Chem
; 23(10): 2328-43, 2015 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25882520
7.
Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation.
Bioorg Med Chem Lett
; 23(4): 1114-9, 2013 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23260349
8.
Applying HT-SAXS to chemical ligand screening.
Methods Enzymol
; 678: 331-350, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-36641213
9.
Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects.
Antioxidants (Basel)
; 12(11)2023 Nov 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-38001840
10.
GRB2 enforces homology-directed repair initiation by MRE11.
Sci Adv
; 7(32)2021 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-34348893
11.
An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2.
Methods Enzymol
; 661: 407-431, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34776222
12.
An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation.
Prog Biophys Mol Biol
; 163: 143-159, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-33675849
13.
Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors.
Prog Biophys Mol Biol
; 163: 171-186, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-33636189
14.
Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun
; 10(1): 5654, 2019 12 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31827085
15.
Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor.
DNA Repair (Amst)
; 60: 29-39, 2017 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29078112
16.
Design, parallel synthesis, and crystal structures of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex.
J Med Chem
; 46(19): 4050-62, 2003 Sep 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-12954058
17.
Inhibitors of HGFA, Matriptase, and Hepsin Serine Proteases: A Nonkinase Strategy to Block Cell Signaling in Cancer.
ACS Med Chem Lett
; 5(11): 1219-24, 2014 Nov 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-25408834
18.
Erratum to "Structure-activity relationships among DNA ligase inhibitors; characterization of a selective uncompetitive DNA ligase I inhibitor" [DNA Repair 60C (2017) 29-39].
DNA Repair (Amst)
; 61: 99, 2018 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29273192
19.
Structure-based drug design of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex.
Bioorg Med Chem Lett
; 13(14): 2319-25, 2003 Jul 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-12824026
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