Detalles de la búsqueda
1.
Real-world application of PBPK in drug discovery.
Drug Metab Dispos
; 2023 Dec 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-38123941
2.
Physiologically Based Pharmacokinetic Modeling To Predict Drug-Biologic Interactions with Cytokine Modulators: Are These Relevant and Is Interleukin-6 Enough?
Drug Metab Dispos
; 50(10): 1322-1331, 2022 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36100353
3.
Cure4Kids: Two decades of knowledge transfer.
Pediatr Blood Cancer
; 69(12): e30007, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-36129384
4.
Using facial muscular movements to understand young children's emotion regulation and concurrent neural activation.
Dev Sci
; 21(5): e12628, 2018 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-29226482
5.
Evaluation of the antitumor effects of c-Myc-Max heterodimerization inhibitor 100258-F4 in ovarian cancer cells.
J Transl Med
; 12: 226, 2014 Aug 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-25143136
6.
Physiologically-based pharmacokinetic modeling of the drug-drug interaction between ivacaftor and lefamulin in cystic fibrosis patients.
CPT Pharmacometrics Syst Pharmacol
; 13(4): 589-598, 2024 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-38303579
7.
Creation of Novel Sensitive Probe Substrate and Moderate Inhibitor Models for a Comprehensive Prediction of CYP2C8 Interactions for Tucatinib.
Clin Pharmacol Ther
; 115(2): 299-308, 2024 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-37971208
8.
Predicting pharmacokinetic profiles using in silico derived parameters.
Mol Pharm
; 10(4): 1207-15, 2013 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23427934
9.
A mathematical model of the human menstrual cycle for the administration of GnRH analogues.
J Theor Biol
; 321: 8-27, 2013 Mar 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-23206386
10.
Tiered approach to evaluate the CYP3A victim and perpetrator drug-drug interaction potential for vonoprazan using PBPK modeling and clinical data to inform labeling.
CPT Pharmacometrics Syst Pharmacol
; 12(4): 532-544, 2023 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36896795
11.
Physiologically Based Pharmacokinetic Model Development and Verification for Bioequivalence Testing of Bempedoic Acid Oral Suspension and Reference Tablet Formulation.
Pharmaceutics
; 15(5)2023 May 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-37242718
12.
A comprehensive evaluation in clinic and physiologically-based pharmacokinetic modeling and simulation to confirm lack of cytochrome P450-mediated drug-drug interaction potential for pomotrelvir.
CPT Pharmacometrics Syst Pharmacol
; 12(10): 1553-1564, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37614073
13.
Development and application of a PBPK modeling strategy to support antimalarial drug development.
CPT Pharmacometrics Syst Pharmacol
; 12(9): 1335-1346, 2023 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37587640
14.
In vitro evaluation of hepatic transporter-mediated clinical drug-drug interactions: hepatocyte model optimization and retrospective investigation.
Drug Metab Dispos
; 40(6): 1085-92, 2012 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-22381335
15.
Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data.
Drug Metab Dispos
; 40(5): 1007-17, 2012 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-22344703
16.
Use of modelling and simulation techniques to support decision making on the progression of PF-04878691, a TLR7 agonist being developed for hepatitis C.
Br J Clin Pharmacol
; 73(1): 77-92, 2012 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-21689140
17.
The evolution of the OATP hepatic uptake transport protein family in DMPK sciences: from obscure liver transporters to key determinants of hepatobiliary clearance.
Xenobiotica
; 42(1): 28-45, 2012 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-22077101
18.
Application of PBPK modelling in drug discovery and development at Pfizer.
Xenobiotica
; 42(1): 94-106, 2012 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-22035569
19.
Opportunities and Challenges for PBPK Model of mAbs in Paediatrics and Pregnancy.
AAPS J
; 24(4): 72, 2022 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35650328
20.
Outcomes of Children With Low-Grade Gliomas in Low- and Middle-Income Countries: A Systematic Review.
JCO Glob Oncol
; 8: e2200199, 2022 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36198134