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1.
E. coli and the etiology of human PBC: Antimitochondrial antibodies and spreading determinants.
Hepatology
; 75(2): 266-279, 2022 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34608663
2.
Probing the E1o-E2o and E1a-E2o Interactions in Binary Subcomplexes of the Human 2-Oxoglutarate Dehydrogenase and 2-Oxoadipate Dehydrogenase Complexes by Chemical Cross-Linking Mass Spectrometry and Molecular Dynamics Simulation.
Int J Mol Sci
; 24(5)2023 Feb 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-36901986
3.
DHTKD1 and OGDH display substrate overlap in cultured cells and form a hybrid 2-oxo acid dehydrogenase complex in vivo.
Hum Mol Genet
; 29(7): 1168-1179, 2020 05 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32160276
4.
Functional Versatility of the Human 2-Oxoadipate Dehydrogenase in the L-Lysine Degradation Pathway toward Its Non-Cognate Substrate 2-Oxopimelic Acid.
Int J Mol Sci
; 23(15)2022 Jul 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-35897808
5.
Structures of the Most Twisted Thioamide and Selenoamide: Effect of Higher Chalcogens of Twisted Amides on N-C(X) Resonance.
Angew Chem Int Ed Engl
; 61(35): e202207346, 2022 08 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-35776856
6.
Structure-function analyses of the G729R 2-oxoadipate dehydrogenase genetic variant associated with a disorder of l-lysine metabolism.
J Biol Chem
; 295(23): 8078-8095, 2020 06 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-32303640
7.
Underlying molecular alterations in human dihydrolipoamide dehydrogenase deficiency revealed by structural analyses of disease-causing enzyme variants.
Hum Mol Genet
; 28(20): 3339-3354, 2019 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31334547
8.
Conformational dynamics of 1-deoxy-d-xylulose 5-phosphate synthase on ligand binding revealed by H/D exchange MS.
Proc Natl Acad Sci U S A
; 114(35): 9355-9360, 2017 08 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-28808005
9.
Active Site Histidines Link Conformational Dynamics with Catalysis on Anti-Infective Target 1-Deoxy-d-xylulose 5-Phosphate Synthase.
Biochemistry
; 58(49): 4970-4982, 2019 12 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31724401
10.
Pyruvate dehydrogenase complex deficiency is linked to regulatory loop disorder in the αV138M variant of human pyruvate dehydrogenase.
J Biol Chem
; 293(34): 13204-13213, 2018 08 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-29970614
11.
Oxidative decarboxylation of pyruvate by 1-deoxy-d-xyulose 5-phosphate synthase, a central metabolic enzyme in bacteria.
J Biol Chem
; 293(28): 10857-10869, 2018 07 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-29784878
12.
A multipronged approach unravels unprecedented protein-protein interactions in the human 2-oxoglutarate dehydrogenase multienzyme complex.
J Biol Chem
; 293(50): 19213-19227, 2018 12 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30323066
13.
Human 2-Oxoglutarate Dehydrogenase and 2-Oxoadipate Dehydrogenase Both Generate Superoxide/H2O2 in a Side Reaction and Each Could Contribute to Oxidative Stress in Mitochondria.
Neurochem Res
; 44(10): 2325-2335, 2019 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-30847859
14.
Evidence for functional and regulatory cross-talk between the tricarboxylic acid cycle 2-oxoglutarate dehydrogenase complex and 2-oxoadipate dehydrogenase on the l-lysine, l-hydroxylysine and l-tryptophan degradation pathways from studies in vitro.
Biochim Biophys Acta Bioenerg
; 1859(9): 932-939, 2018 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-29752936
15.
Structural alterations induced by ten disease-causing mutations of human dihydrolipoamide dehydrogenase analyzed by hydrogen/deuterium-exchange mass spectrometry: Implications for the structural basis of E3 deficiency.
Biochim Biophys Acta
; 1862(11): 2098-2109, 2016 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-27544700
16.
Ruthenium(ii)-catalyzed ortho-C-H arylation of diverse N-heterocycles with aryl silanes by exploiting solvent-controlled N-coordination.
Org Biomol Chem
; 15(22): 4783-4788, 2017 Jun 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-28440829
17.
Competence of Thiamin Diphosphate-Dependent Enzymes with 2'-Methoxythiamin Diphosphate Derived from Bacimethrin, a Naturally Occurring Thiamin Anti-vitamin.
Biochemistry
; 55(7): 1135-48, 2016 Feb 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-26813608
18.
Elucidation of the interaction loci of the human pyruvate dehydrogenase complex E2·E3BP core with pyruvate dehydrogenase kinase 1 and kinase 2 by H/D exchange mass spectrometry and nuclear magnetic resonance.
Biochemistry
; 54(1): 69-82, 2015 Jan 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-25436986
19.
The pyruvate dehydrogenase complexes: structure-based function and regulation.
J Biol Chem
; 289(24): 16615-23, 2014 Jun 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-24798336
20.
Human 2-oxoglutarate dehydrogenase complex E1 component forms a thiamin-derived radical by aerobic oxidation of the enamine intermediate.
J Biol Chem
; 289(43): 29859-73, 2014 Oct 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-25210035