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1.
Disposition of Nirmatrelvir, an Orally Bioavailable Inhibitor of SARS-CoV-2 3C-Like Protease, across Animals and Humans.
Drug Metab Dispos
; 50(5): 576-590, 2022 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35153195
2.
Estimation of Circulating Drug Metabolite Exposure in Human Using In Vitro Data and Physiologically Based Pharmacokinetic Modeling: Example of a High Metabolite/Parent Drug Ratio.
Drug Metab Dispos
; 46(2): 89-99, 2018 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29150544
3.
Inception and development of a LC-MS/MS assay for the multiplexed quantitation of nine human drug transporter biomarkers.
Bioanalysis
; 16(6): 347-362, 2024 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-38376139
4.
A Novel Milli-fluidic Liver Tissue Chip with Continuous Recirculation for Predictive Pharmacokinetics Applications.
AAPS J
; 25(6): 102, 2023 10 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-37891356
5.
Metabolism and Excretion of Nirmatrelvir in Humans Using Quantitative Fluorine Nuclear Magnetic Resonance Spectroscopy: A Novel Approach for Accelerating Drug Development.
Clin Pharmacol Ther
; 112(6): 1201-1206, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-35678736
6.
Innovative Randomized Phase I Study and Dosing Regimen Selection to Accelerate and Inform Pivotal COVID-19 Trial of Nirmatrelvir.
Clin Pharmacol Ther
; 112(1): 101-111, 2022 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35388471
7.
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19.
Nat Commun
; 12(1): 6055, 2021 10 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-34663813
8.
Discovery of a Novel Inhibitor of Coronavirus 3CL Protease for the Potential Treatment of COVID-19.
bioRxiv
; 2021 Feb 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-32935104
9.
An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19.
Science
; 374(6575): 1586-1593, 2021 Dec 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-34726479
10.
Application of hydrophilic interaction chromatography retention coefficients for predicting peptide elution with TFA and methanesulfonic acid ion-pairing reagents.
J Sep Sci
; 33(6-7): 826-33, 2010 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-20087867
11.
Remediation of undesirable secondary interactions encountered in hydrophilic interaction chromatography during development of a quantitative LC-MS/MS assay for a dipeptidyl peptidase IV (DPP-IV) inhibitor in monkey serum.
J Chromatogr B Analyt Technol Biomed Life Sci
; 877(5-6): 471-6, 2009 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19162567
12.
Rapid determination of the applicability of hydrophilic interaction chromatography utilizing ACD labs log D suite: a bioanalytical application.
J Chromatogr B Analyt Technol Biomed Life Sci
; 863(1): 1-8, 2008 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18255356
13.
Correction: A Novel Milli-fluidic Liver Tissue Chip with Continuous Recirculation for Predictive Pharmacokinetics Applications.
AAPS J
; 26(1): 2, 2023 Nov 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-37985630
14.
Evaluation of the relationship between a pharmaceutical compound's distribution coefficient, log D and adsorption loss to polypropylene in urine and CSF.
Bioanalysis
; 2(4): 755-67, 2010 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-21083273
15.
Reduction of in-source collision-induced dissociation and thermolysis of sulopenem prodrugs for quantitative liquid chromatography/electrospray ionization mass spectrometric analysis by promoting sodium adduct formation.
Rapid Commun Mass Spectrom
; 22(20): 3195-206, 2008 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-18803331
16.
Initial rate analysis of zoniporide hydrolysis degradants using high-performance liquid chromatography coupled with mass spectrometric detection.
Pharm Dev Technol
; 12(3): 247-57, 2007.
Artículo
en Inglés
| MEDLINE | ID: mdl-17613888
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