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1.
Design, synthesis, and biological evaluation of 3-aryl-3-hydroxy-1-phenylpyrrolidine derivatives as novel androgen receptor antagonists.
Bioorg Med Chem
; 21(1): 70-83, 2013 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23199477
2.
Design, synthesis, and biological evaluation of 4-arylmethyl-1-phenylpyrazole and 4-aryloxy-1-phenylpyrazole derivatives as novel androgen receptor antagonists.
Bioorg Med Chem
; 20(7): 2338-52, 2012 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22391033
3.
17,20-lyase inhibitors. Part 4: design, synthesis and structure-activity relationships of naphthylmethylimidazole derivatives as novel 17,20-lyase inhibitors.
Bioorg Med Chem
; 19(5): 1751-70, 2011 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21316976
4.
17,20-Lyase inhibitors. Part 3: Design, synthesis, and structure-activity relationships of biphenylylmethylimidazole derivatives as novel 17,20-lyase inhibitors.
Bioorg Med Chem
; 19(7): 2428-42, 2011 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21429754
5.
Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer.
Bioorg Med Chem
; 19(21): 6383-99, 2011 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21978946
6.
Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement.
Sci Rep
; 11(1): 14532, 2021 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34267258
7.
TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window.
Neuropsychopharmacology
; 44(5): 961-970, 2019 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-30209408
8.
Author Correction: Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement.
Sci Rep
; 11(1): 15255, 2021 Jul 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-34290388
9.
Different effects of eNOS and nNOS inhibition on transient forebrain ischemia.
Brain Res
; 946(1): 139-47, 2002 Aug 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-12133603
10.
Inhibition of high K+-evoked gamma-aminobutyric acid release by sodium nitroprusside in rat hippocampus.
Eur J Pharmacol
; 467(1-3): 119-23, 2003 Apr 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-12706464
11.
Effect of a novel 17,20-lyase inhibitor, orteronel (TAK-700), on androgen synthesis in male rats.
J Steroid Biochem Mol Biol
; 134: 80-91, 2013 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-23146910
12.
Effect of an investigational CYP17A1 inhibitor, orteronel (TAK-700), on estrogen- and corticoid-synthesis pathways in hypophysectomized female rats and on the serum estradiol levels in female cynomolgus monkeys.
J Steroid Biochem Mol Biol
; 138: 298-306, 2013 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-23856460
13.
Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys.
J Steroid Biochem Mol Biol
; 129(3-5): 115-28, 2012 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-22249003
14.
C(17,20)-lyase inhibitors. Part 2: design, synthesis and structure-activity relationships of (2-naphthylmethyl)-1H-imidazoles as novel C(17,20)-lyase inhibitors.
Bioorg Med Chem
; 12(16): 4313-36, 2004 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-15265485
15.
C17,20-lyase inhibitors I. Structure-based de novo design and SAR study of C17,20-lyase inhibitors.
Bioorg Med Chem
; 12(9): 2251-73, 2004 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15080924
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