Detalles de la búsqueda
1.
Translational PK/PD framework for antibody-drug conjugates to inform drug discovery and development.
Xenobiotica
; : 1-11, 2024 May 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-38738473
2.
Characterization of Tissue Distribution, Catabolism, and Elimination of an Anti-Staphylococcus aureus THIOMAB Antibody-Antibiotic Conjugate in Rats.
Drug Metab Dispos
; 48(11): 1161-1168, 2020 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32839277
3.
Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα).
Bioorg Med Chem Lett
; 30(4): 126907, 2020 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31902710
4.
A Phase 1, Randomized, Single-Ascending-Dose Study To Investigate the Safety, Tolerability, and Pharmacokinetics of DSTA4637S, an Anti-Staphylococcus aureus Thiomab Antibody-Antibiotic Conjugate, in Healthy Volunteers.
Antimicrob Agents Chemother
; 63(6)2019 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-30910894
5.
Antibody-Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo.
Bioconjug Chem
; 30(5): 1356-1370, 2019 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30966735
6.
Current Approaches for Absorption, Distribution, Metabolism, and Excretion Characterization of Antibody-Drug Conjugates: An Industry White Paper.
Drug Metab Dispos
; 44(5): 617-23, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26669328
7.
Translational pharmacokinetics and pharmacodynamics of monoclonal antibodies.
Drug Discov Today Technol
; 21-22: 75-83, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27978991
8.
Peripheral neuropathy with microtubule inhibitor containing antibody drug conjugates: Challenges and perspectives in translatability from nonclinical toxicology studies to the clinic.
Regul Toxicol Pharmacol
; 82: 1-13, 2016 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-27773754
9.
Challenges and advances in the assessment of the disposition of antibody-drug conjugates.
Biopharm Drug Dispos
; 37(2): 66-74, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-25904406
10.
Preclinical Pharmacokinetic Considerations for the Development of Antibody Drug Conjugates.
Pharm Res
; 32(11): 3470-9, 2015 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-25446773
11.
A Bispecific Modeling Framework Enables the Prediction of Efficacy, Toxicity, and Optimal Molecular Design of Bispecific Antibodies Targeting MerTK.
AAPS J
; 26(1): 11, 2024 01 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-38167740
12.
A Minimal PBPK/PD Model with Expansion-Enhanced Target-Mediated Drug Disposition to Support a First-in-Human Clinical Study Design for a FLT3L-Fc Molecule.
Pharmaceutics
; 16(5)2024 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38794321
13.
Utilizing PK and PD Biomarkers to Guide the First-in-Human Starting Dose Selection of MTBT1466A: A Novel Humanized Monoclonal Anti-TGFß3 Antibody for the Treatment of Fibrotic Diseases.
J Pharm Sci
; 112(11): 2910-2920, 2023 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-37429356
14.
Non-human primates in the PKPD evaluation of biologics: Needs and options to reduce, refine, and replace. A BioSafe White Paper.
MAbs
; 14(1): 2145997, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36418217
15.
Effect of molecular size on interstitial pharmacokinetics and tissue catabolism of antibodies.
MAbs
; 14(1): 2085535, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35867780
16.
Nonclinical Pharmacokinetics, Pharmacodynamics, and Translational Model of RO7297089, A Novel Anti-BCMA/CD16A Bispecific Tetravalent Antibody for the Treatment of Multiple Myeloma.
AAPS J
; 24(6): 100, 2022 09 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-36127472
17.
Nonclinical Pharmacokinetics and Pharmacodynamics Characterization of Anti-CD79b/CD3 T Cell-Dependent Bispecific Antibody Using a Surrogate Molecule: A Potential Therapeutic Agent for B Cell Malignancies.
Pharmaceutics
; 14(5)2022 Apr 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-35631556
18.
Antibody Format and Serum Disposition Govern Ocular Pharmacokinetics of Intravenously Administered Protein Therapeutics.
Front Pharmacol
; 12: 601569, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34025395
19.
Imaging Reveals Importance of Shape and Flexibility for Glomerular Filtration of Biologics.
Mol Cancer Ther
; 20(10): 2008-2015, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34315765
20.
Valency of HER2 Targeting Antibodies Influences Tumor Cell Internalization and Penetration.
Mol Cancer Ther
; 20(10): 1956-1965, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34253591