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1.
Design and synthesis of a novel 2-oxindole scaffold as a highly potent and brain-penetrant phosphodiesterase 10A inhibitor.
Bioorg Med Chem
; 23(22): 7138-49, 2015 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26494583
2.
A 96-well plate assay for CYP4503A induction using cryopreserved human hepatocytes.
Drug Metab Dispos
; 38(11): 1912-6, 2010 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-20699409
3.
Discovery of an Orally Bioavailable, Brain-Penetrating, in Vivo Active Phosphodiesterase 2A Inhibitor Lead Series for the Treatment of Cognitive Disorders.
J Med Chem
; 60(18): 7658-7676, 2017 09 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-28759228
4.
Discovery of Clinical Candidate N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders.
J Med Chem
; 60(18): 7677-7702, 2017 09 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-28796496
5.
Characterization of binding and inhibitory properties of TAK-063, a novel phosphodiesterase 10A inhibitor.
PLoS One
; 10(3): e0122197, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25815469
6.
Characterization of the binding properties of T-773 as a PET radioligand for phosphodiesterase 10A.
Nucl Med Biol
; 42(2): 146-54, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25451212
7.
Discovery of 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a highly potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor.
J Med Chem
; 57(22): 9627-43, 2014 Nov 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-25384088
8.
Characterization of the CYP2C8 active site by homology modeling.
Chem Pharm Bull (Tokyo)
; 52(7): 836-41, 2004 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-15256704
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