Detalles de la búsqueda
1.
In Vivo and In Vitro Characterization of Close Analogs of Compound KA-11, a New Antiseizure Drug Candidate.
Int J Mol Sci
; 24(9)2023 May 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37176010
2.
Antinociceptive and Antiallodynic Activity of Some 3-(3-Methylthiophen-2-yl)pyrrolidine-2,5-dione Derivatives in Mouse Models of Tonic and Neuropathic Pain.
Int J Mol Sci
; 23(7)2022 Apr 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35409413
3.
Asymmetric synthesis and in vivo/in vitro characterization of new hybrid anticonvulsants derived from (2,5-dioxopyrrolidin-1-yl)phenylacetamides.
Bioorg Chem
; 109: 104751, 2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33647745
4.
Synthesis, anticonvulsant, and antinociceptive activity of new 3-(3-methyl-2,5-dioxo-3-phenylpyrrolidin-1-yl)propanamides and 3-phenyl-butanamides.
Arch Pharm (Weinheim)
; 354(1): e2000225, 2021 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-32939789
5.
Preclinical Assessment of a New Hybrid Compound C11 Efficacy on Neurogenesis and Cognitive Functions after Pilocarpine Induced Status Epilepticus in Mice.
Int J Mol Sci
; 22(6)2021 Mar 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-33810180
6.
Identification of New Compounds with Anticonvulsant and Antinociceptive Properties in a Group of 3-substituted (2,5-dioxo-pyrrolidin-1-yl)(phenyl)-Acetamides.
Int J Mol Sci
; 22(23)2021 Dec 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-34884898
7.
Synthesis, Anticonvulsant, and Antinociceptive Activity of New 3-(2-Chlorophenyl)- and 3-(3-Chlorophenyl)-2,5-dioxo-pyrrolidin-1-yl-acetamides.
Molecules
; 26(6)2021 Mar 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33809109
8.
C-11, a New Antiepileptic Drug Candidate: Evaluation of the Physicochemical Properties and Impact on the Protective Action of Selected Antiepileptic Drugs in the Mouse Maximal Electroshock-Induced Seizure Model.
Molecules
; 26(11)2021 May 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-34074008
9.
KA-104, a new multitargeted anticonvulsant with potent antinociceptive activity in preclinical models.
Epilepsia
; 61(10): 2119-2128, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32929733
10.
The Search for New Anticonvulsants in a Group of (2,5-Dioxopyrrolidin-1-yl)(phenyl)Acetamides with Hybrid Structure-Synthesis and In Vivo/In Vitro Studies.
Int J Mol Sci
; 21(22)2020 Nov 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-33233618
11.
Synthesis and Anticonvulsant Properties of New 3,3-Diphenyl-2,5-dioxo-pyrrolidin-1-yl-acetamides and 3,3-Diphenyl-propionamides.
Arch Pharm (Weinheim)
; 350(3-4)2017 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-28317156
12.
Design, synthesis and anticonvulsant activity of new hybrid compounds derived from N-phenyl-2-(2,5-dioxopyrrolidin-1-yl)-propanamides and -butanamides.
Bioorg Med Chem
; 24(13): 2938-2946, 2016 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27211245
13.
Synthesis, and anticonvulsant activity of new amides derived from 3-methyl- or 3-ethyl-3-methyl-2,5-dioxo-pyrrolidin-1-yl-acetic acids.
Bioorg Med Chem
; 24(8): 1598-607, 2016 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26970661
14.
New hybrid molecules with anticonvulsant and antinociceptive activity derived from 3-methyl- or 3,3-dimethyl-1-[1-oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl]pyrrolidine-2,5-diones.
Bioorg Med Chem
; 24(4): 606-18, 2016 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26746343
15.
Design, synthesis and biological evaluation of new hybrid anticonvulsants derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide derivatives.
Bioorg Med Chem
; 23(10): 2548-61, 2015 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25868743
16.
Synthesis and anticonvulsant activity of new N-phenyl-2-(4-phenylpiperazin-1-yl)acetamide derivatives.
Med Chem Res
; 24(7): 3047-3061, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-26167103
17.
Synthesis, anticonvulsant properties, and SAR analysis of differently substituted pyrrolidine-2,5-diones and piperidine-2,6-diones.
Arch Pharm (Weinheim)
; 347(11): 840-52, 2014 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-25196991
18.
Synthesis, physicochemical, and anticonvulsant properties of new N-Mannich bases derived from pyrrolidine-2,5-dione and its 3-methyl analog.
Arch Pharm (Weinheim)
; 347(10): 768-76, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-25139813
19.
TRPV1 channel in the pathophysiology of epilepsy and its potential as a molecular target for the development of new antiseizure drug candidates.
Prog Neurobiol
; 240: 102634, 2024 Jun 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-38834133
20.
A comprehensive assessment of palmatine as anticonvulsant agent - In vivo and in silico studies.
Biomed Pharmacother
; 172: 116234, 2024 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-38325264