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1.
Novel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases.
Bioorg Med Chem Lett
; 23(15): 4381-7, 2013 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23773865
2.
Cooperative signaling between oncostatin M, hepatocyte growth factor and transforming growth factor-ß enhances epithelial to mesenchymal transition in lung and pancreatic tumor models.
Cells Tissues Organs
; 193(1-2): 114-32, 2011.
Artículo
en Inglés
| MEDLINE | ID: mdl-21041998
3.
Evaluation of the dual mTOR/PI3K inhibitors Gedatolisib (PF-05212384) and PF-04691502 against ovarian cancer xenograft models.
Sci Rep
; 9(1): 18742, 2019 12 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31822716
4.
Colon carcinoma cells harboring PIK3CA mutations display resistance to growth factor deprivation induced apoptosis.
Mol Cancer Ther
; 6(3): 1143-50, 2007 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-17363507
5.
Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR.
Sci Signal
; 7(351): ra107, 2014 Nov 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-25389372
6.
Tumor P-Glycoprotein Correlates with Efficacy of PF-3758309 in in vitro and in vivo Models of Colorectal Cancer.
Front Pharmacol
; 4: 22, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-23524533
7.
Molecular predictors of sensitivity to the insulin-like growth factor 1 receptor inhibitor Figitumumab (CP-751,871).
Mol Cancer Ther
; 12(12): 2929-39, 2013 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-24107449
8.
Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation.
Clin Cancer Res
; 19(11): 2929-40, 2013 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23403635
9.
Evaluation of the antitumor effects and mechanisms of PF00299804, a pan-HER inhibitor, alone or in combination with chemotherapy or targeted agents in gastric cancer.
Mol Cancer Ther
; 11(2): 439-51, 2012 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-22135232
10.
Combination of a MEK inhibitor at sub-MTD with a PI3K/mTOR inhibitor significantly suppresses growth of lung adenocarcinoma tumors in Kras(G12D-LSL) mice.
Cancer Chemother Pharmacol
; 70(2): 213-20, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22684718
11.
An integrated genomic approach to identify predictive biomarkers of response to the aurora kinase inhibitor PF-03814735.
Mol Cancer Ther
; 11(3): 710-9, 2012 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-22222631
12.
Inducible expression of TGFß, snail and Zeb1 recapitulates EMT in vitro and in vivo in a NSCLC model.
Clin Exp Metastasis
; 28(7): 593-614, 2011 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-21643654
13.
PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity.
Mol Cancer Ther
; 10(11): 2189-99, 2011 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-21750219
14.
Knockdown of Ron kinase inhibits mutant phosphatidylinositol 3-kinase and reduces metastasis in human colon carcinoma.
J Biol Chem
; 284(16): 10912-22, 2009 Apr 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-19224914
15.
3-[6-(2-Dimethylamino-1-imidazol-1-yl-butyl)-naphthalen-2-yloxy]-2,2-dimethyl-propionic acid as a highly potent and selective retinoic acid metabolic blocking agent.
Bioorg Med Chem Lett
; 16(10): 2729-33, 2006 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16504501
16.
Potent and selective [2-imidazol-1-yl-2-(6-alkoxy-naphthalen-2-yl)-1-methyl-ethyl]-dimethyl-amines as retinoic acid metabolic blocking agents (RAMBAs).
Bioorg Med Chem Lett
; 15(6): 1669-73, 2005 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-15745819
17.
Arginine-serine-rich domains bound at splicing enhancers contact the branchpoint to promote prespliceosome assembly.
Mol Cell
; 13(3): 367-76, 2004 Feb 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-14967144
18.
A single polypyrimidine tract binding protein (PTB) binding site mediates splicing inhibition at mouse IgM exons M1 and M2.
RNA
; 10(5): 787-94, 2004 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-15100434
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