Detalles de la búsqueda
1.
Trisubstituted 1,3,5-Triazines as Histamine H4 Receptor Antagonists with Promising Activity In Vivo.
Molecules
; 28(10)2023 May 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-37241939
2.
Preclinical evaluation of 1,2,4-triazole-based compounds targeting voltage-gated sodium channels (VGSCs) as promising anticonvulsant drug candidates.
Bioorg Chem
; 94: 103355, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31662213
3.
Dual Target Ligands with 4-tert-Butylphenoxy Scaffold as Histamine H3 Receptor Antagonists and Monoamine Oxidase B Inhibitors.
Int J Mol Sci
; 21(10)2020 May 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-32408504
4.
Novel multi-target directed ligands based on annelated xanthine scaffold with aromatic substituents acting on adenosine receptor and monoamine oxidase B. Synthesis, in vitro and in silico studies.
Bioorg Med Chem
; 27(7): 1195-1210, 2019 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30808606
5.
Structural modifications and in vitro pharmacological evaluation of 4-pyridyl-piperazine derivatives as an active and selective histamine H3 receptor ligands.
Bioorg Chem
; 91: 103071, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31362197
6.
4-tert-Pentylphenoxyalkyl derivatives - Histamine H3 receptor ligands and monoamine oxidase B inhibitors.
Bioorg Med Chem Lett
; 28(23-24): 3596-3600, 2018 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30404719
7.
Optimization and preclinical evaluation of novel histamine H3receptor ligands: Acetyl and propionyl phenoxyalkyl piperazine derivatives.
Bioorg Med Chem
; 26(23-24): 6056-6066, 2018 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30448256
8.
Novel naphthyloxy derivatives - Potent histamine H3 receptor ligands. Synthesis and pharmacological evaluation.
Bioorg Med Chem
; 26(9): 2573-2585, 2018 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29681486
9.
Synthesis and biological activity of novel tert-amylphenoxyalkyl (homo)piperidine derivatives as histamine H3R ligands.
Bioorg Med Chem
; 25(10): 2701-2712, 2017 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28372935
10.
Biphenyloxy-alkyl-piperidine and azepane derivatives as histamine H3 receptor ligands.
Bioorg Med Chem
; 25(20): 5341-5354, 2017 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28797771
11.
Molecular mechanism of action and safety of 5-(3-chlorophenyl)-4-hexyl-2,4-dihydro-3H-1,2,4-triazole-3-thione - a novel anticonvulsant drug candidate.
Int J Med Sci
; 14(8): 741-749, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28824309
12.
Novel Piperazine Arylideneimidazolones Inhibit the AcrAB-TolC Pump in Escherichia coli and Simultaneously Act as Fluorescent Membrane Probes in a Combined Real-Time Influx and Efflux Assay.
Antimicrob Agents Chemother
; 60(4): 1974-83, 2016 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-26824939
13.
Chlorophenoxy aminoalkyl derivatives as histamine H(3)R ligands and antiseizure agents.
Bioorg Med Chem
; 24(2): 53-72, 2016 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26690914
14.
Similarities and differences in affinity and binding modes of tricyclic pyrimido- and pyrazinoxanthines at human and rat adenosine receptors.
Bioorg Med Chem
; 24(18): 4347-4362, 2016 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27485602
15.
Synthesis and Analgesic Activity of Annelated Xanthine Derivatives in Experimental Models in Rodents.
Arch Pharm (Weinheim)
; 348(10): 704-14, 2015 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-26248713
16.
4-Oxypiperidine Ethers as Multiple Targeting Ligands at Histamine H3 Receptors and Cholinesterases.
ACS Chem Neurosci
; 15(6): 1206-1218, 2024 Mar 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-38440987
17.
First-in-Class Selenium-Containing Potent Serotonin Receptor 5-HT6 Agents with a Beneficial Neuroprotective Profile against Alzheimer's Disease.
J Med Chem
; 67(2): 1580-1610, 2024 Jan 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-38190615
18.
Synthesis, biological activity and molecular modelling studies of tricyclic alkylimidazo-, pyrimido- and diazepinopurinediones.
Purinergic Signal
; 9(3): 395-414, 2013 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-23543220
19.
2-(4-Fluorophenyl)-1H-benzo[d]imidazole as a Promising Template for the Development of Metabolically Robust, α1ß2γ2GABA-A Receptor-Positive Allosteric Modulators.
ACS Chem Neurosci
; 14(6): 1166-1180, 2023 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36848624
20.
Xanthine-Dopamine Hybrid Molecules as Multitarget Drugs with Potential for the Treatment of Neurodegenerative Diseases.
Biomolecules
; 13(7)2023 07 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37509114