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1.
Intra-S phase checkpoint kinase Chk1 dissociates replication proteins Treslin and TopBP1 through multiple mechanisms during replication stress.
J Biol Chem
; 298(4): 101777, 2022 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-35231445
2.
DAGBagM: learning directed acyclic graphs of mixed variables with an application to identify protein biomarkers for treatment response in ovarian cancer.
BMC Bioinformatics
; 23(1): 321, 2022 Aug 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35931981
3.
Glycogen Synthase Kinase 3 (GSK-3)-mediated Phosphorylation of Uracil N-Glycosylase 2 (UNG2) Facilitates the Repair of Floxuridine-induced DNA Lesions and Promotes Cell Survival.
J Biol Chem
; 291(52): 26875-26885, 2016 Dec 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-27875297
4.
Genomically Incorporated 5-Fluorouracil that Escapes UNG-Initiated Base Excision Repair Blocks DNA Replication and Activates Homologous Recombination.
Mol Pharmacol
; 89(1): 53-62, 2016 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-26494862
5.
Ovarian cancer-associated mutations disable catalytic activity of CDK12, a kinase that promotes homologous recombination repair and resistance to cisplatin and poly(ADP-ribose) polymerase inhibitors.
J Biol Chem
; 289(13): 9247-53, 2014 Mar 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-24554720
6.
Identification of DNA repair pathways that affect the survival of ovarian cancer cells treated with a poly(ADP-ribose) polymerase inhibitor in a novel drug combination.
Mol Pharmacol
; 82(4): 767-76, 2012 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-22833573
7.
A phase II study of gemcitabine in combination with tanespimycin in advanced epithelial ovarian and primary peritoneal carcinoma.
Gynecol Oncol
; 124(2): 210-5, 2012 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-22047770
8.
Repurposing Ceritinib Induces DNA Damage and Enhances PARP Inhibitor Responses in High-Grade Serous Ovarian Carcinoma.
Cancer Res
; 82(2): 307-319, 2022 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34810199
9.
Phase I and pharmacological study of cytarabine and tanespimycin in relapsed and refractory acute leukemia.
Haematologica
; 96(11): 1619-26, 2011 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-21791475
10.
VLX600 Disrupts Homologous Recombination and Synergizes with PARP Inhibitors and Cisplatin by Inhibiting Histone Lysine Demethylases.
Mol Cancer Ther
; 20(9): 1561-1571, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34224364
11.
Enzymatic activation of pyruvate kinase increases cytosolic oxaloacetate to inhibit the Warburg effect.
Nat Metab
; 3(7): 954-968, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-34226744
12.
CDK2-Mediated Upregulation of TNFα as a Mechanism of Selective Cytotoxicity in Acute Leukemia.
Cancer Res
; 81(10): 2666-2678, 2021 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33414171
13.
Multiomic analysis identifies CPT1A as a potential therapeutic target in platinum-refractory, high-grade serous ovarian cancer.
Cell Rep Med
; 2(12): 100471, 2021 12 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-35028612
14.
Characterization of a RAD51C-silenced high-grade serous ovarian cancer model during development of PARP inhibitor resistance.
NAR Cancer
; 3(3): zcab028, 2021 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-34316715
15.
Cisplatin-induced DNA damage activates replication checkpoint signaling components that differentially affect tumor cell survival.
Mol Pharmacol
; 76(1): 208-14, 2009 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-19403702
16.
ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer.
Nat Commun
; 10(1): 4632, 2019 10 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31604914
17.
Effect of CHK1 Inhibition on CPX-351 Cytotoxicity in vitro and ex vivo.
Sci Rep
; 9(1): 3617, 2019 03 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30837643
18.
BRCA1 Deficiency Upregulates NNMT, Which Reprograms Metabolism and Sensitizes Ovarian Cancer Cells to Mitochondrial Metabolic Targeting Agents.
Cancer Res
; 79(23): 5920-5929, 2019 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31619387
19.
Overcoming S-phase checkpoint-mediated resistance: sequence-dependent synergy of gemcitabine and 7-ethyl-10-hydroxycamptothecin (SN-38) in human carcinoma cell lines.
Mol Pharmacol
; 74(3): 724-35, 2008 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-18509065
20.
Cdc37 regulation of the kinome: when to hold 'em and when to fold 'em.
Sci STKE
; 2007(385): pe22, 2007 May 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-17488976