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1.
Discovery of phenylpyrrolidine derivatives as a novel class of retinol binding protein 4 (RBP4) reducers.
Bioorg Med Chem
; 54: 116553, 2022 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34953340
2.
Discovery of novel 5-oxa-2,6-diazaspiro[3.4]oct-6-ene derivatives as potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonists for treatment of type 2 diabetes mellitus.
Bioorg Med Chem
; 25(15): 4175-4193, 2017 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28642028
3.
Discovery of novel somatostatin receptor subtype 5 (SSTR5) antagonists: Pharmacological studies and design to improve pharmacokinetic profiles and human Ether-a-go-go-related gene (hERG) inhibition.
Bioorg Med Chem
; 25(15): 4153-4162, 2017 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28622905
4.
Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel 1-(1H-benzimidazol-6-yl)pyridin-2(1H)-one derivatives and design to avoid CYP3A4 time-dependent inhibition.
Bioorg Med Chem
; 24(11): 2486-503, 2016 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27112449
5.
Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel non-basic 1-(2H-indazole-5-yl)pyridin-2(1H)-one derivatives and mitigation of mutagenicity in Ames test.
Bioorg Med Chem
; 24(11): 2504-18, 2016 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27117261
6.
Melanin-concentrating hormone receptor 1 antagonists: synthesis, structure-activity relationship, docking studies, and biological evaluation of 2,3,4,5-tetrahydro-1H-3-benzazepine derivatives.
Bioorg Med Chem
; 19(21): 6261-73, 2011 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21975069
7.
The enzymatic activity of inositol hexakisphosphate kinase controls circulating phosphate in mammals.
Nat Commun
; 12(1): 4847, 2021 08 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34381031
8.
Bombesin receptor subtype-3-expressing neurons regulate energy homeostasis through a novel neuronal pathway in the hypothalamus.
Brain Behav
; 8(1): e00881, 2018 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29568682
9.
A pyridone derivative activates SERCA2a by attenuating the inhibitory effect of phospholamban.
Eur J Pharmacol
; 814: 1-8, 2017 Nov 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28734932
10.
A novel and selective melanin-concentrating hormone receptor 1 antagonist ameliorates obesity and hepatic steatosis in diet-induced obese rodent models.
Eur J Pharmacol
; 796: 45-53, 2017 Feb 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-27986627
11.
Development of a Novel Carbon-11 Labeled PET Radioligand for Melanin- Concentrating Hormone Receptor 1.
Curr Radiopharm
; 10(1): 35-40, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28034352
12.
A Selective Bombesin Receptor Subtype 3 Agonist Promotes Weight Loss in Male Diet-Induced-Obese Rats With Circadian Rhythm Change.
Endocrinology
; 158(5): 1298-1313, 2017 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28324017
13.
Design, synthesis, and structure-activity relationships of thieno[2,3-b]pyridin-4-one derivatives as a novel class of potent, orally active, non-peptide luteinizing hormone-releasing hormone receptor antagonists.
J Med Chem
; 49(13): 3809-25, 2006 Jun 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-16789738
14.
Melanin-Concentrating Hormone Receptor 1 Antagonists Lacking an Aliphatic Amine: Synthesis and Structure-Activity Relationships of Novel 1-(Imidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one Derivatives.
J Med Chem
; 59(3): 1116-39, 2016 Feb 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-26736071
15.
Melanin-concentrating hormone receptor 1 antagonists. Synthesis and structure-activity relationships of novel 3-(aminomethyl)quinolines.
J Med Chem
; 55(5): 2353-66, 2012 Mar 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-22309223
16.
Synthesis, structure-activity relationship, and pharmacological studies of novel melanin-concentrating hormone receptor 1 antagonists 3-aminomethylquinolines: reducing human ether-a-go-go-related gene (hERG) associated liabilities.
J Med Chem
; 55(9): 4336-51, 2012 May 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-22490048
17.
Correction to Melanin-Concentrating Hormone Receptor 1 Antagonists Lacking an Aliphatic Amine: Synthesis and Structure-Activity Relationships of Novel 1-(Imidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one Derivatives.
J Med Chem
; 59(7): 3577, 2016 Apr 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-27045534
18.
A new class of potent nonpeptide luteinizing hormone-releasing hormone (LHRH) antagonists: design and synthesis of 2-phenylimidazo[1,2-a]pyrimidin-5-ones.
Bioorg Med Chem Lett
; 12(16): 2073-7, 2002 Aug 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-12127507
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