Detalles de la búsqueda
1.
Nuclear Export Inhibitor KPT-8602 Synergizes with PARP Inhibitors in Escalating Apoptosis in Castration Resistant Cancer Cells.
Int J Mol Sci
; 22(13)2021 Jun 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-34206543
2.
A phase 1 clinical trial of single-agent selinexor in acute myeloid leukemia.
Blood
; 129(24): 3165-3174, 2017 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28336527
3.
Selinexor-induced thrombocytopenia results from inhibition of thrombopoietin signaling in early megakaryopoiesis.
Blood
; 130(9): 1132-1143, 2017 08 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-28630120
4.
Deciphering mechanisms of drug sensitivity and resistance to Selective Inhibitor of Nuclear Export (SINE) compounds.
BMC Cancer
; 15: 910, 2015 Nov 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-26573568
5.
Biologic activity of the novel orally bioavailable selective inhibitor of nuclear export (SINE) KPT-335 against canine melanoma cell lines.
BMC Vet Res
; 10: 160, 2014 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25022346
6.
The calcium/calcineurin pathway promotes hemidesmosome stability through inhibition of ß4 integrin phosphorylation.
J Biol Chem
; 287(39): 32440-9, 2012 Sep 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-22865863
7.
A Case Report of a 58-Year-Old Woman with a Diagnosis of High-Risk Myeloma Refractory to Multiple Line of Therapy and Treated with Selinexor, Bortezomib, and Dexamethasone Prior to Allogeneic Stem Cell Transplantation.
Am J Case Rep
; 23: e935353, 2022 Apr 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-35444159
8.
HAPLN1 confers multiple myeloma cell resistance to several classes of therapeutic drugs.
PLoS One
; 17(12): e0274704, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36480501
9.
Selinexor inhibits growth of patient derived chordomas in vivo as a single agent and in combination with abemaciclib through diverse mechanisms.
Front Oncol
; 12: 808021, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36059685
10.
Small Molecule Inhibitors of Nuclear Export and the Amelioration of Lupus by Modulation of Plasma Cell Generation and Survival.
Arthritis Rheumatol
; 74(8): 1363-1375, 2022 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35333447
11.
Role of ß4 integrin phosphorylation in human invasive squamous cell carcinoma: regulation of hemidesmosome stability modulates cell migration.
Lab Invest
; 91(10): 1414-26, 2011 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-21769085
12.
Selinexor, a novel selective inhibitor of nuclear export, reduces SARS-CoV-2 infection and protects the respiratory system in vivo.
Antiviral Res
; 192: 105115, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-34157321
13.
Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-κB Pathway in Preclinical Models of Pediatric High-Grade Glioma.
Mol Cancer Ther
; 19(2): 540-551, 2020 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-31594826
14.
Venetoclax response is enhanced by selective inhibitor of nuclear export compounds in hematologic malignancies.
Blood Adv
; 4(3): 586-598, 2020 02 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32045477
15.
Selinexor reduces the expression of DNA damage repair proteins and sensitizes cancer cells to DNA damaging agents.
Oncotarget
; 9(56): 30773-30786, 2018 Jul 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-30112106
16.
Selinexor synergizes with dexamethasone to repress mTORC1 signaling and induce multiple myeloma cell death.
Oncotarget
; 9(39): 25529-25544, 2018 May 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-29876006
17.
Targeting the XPO1-dependent nuclear export of E2F7 reverses anthracycline resistance in head and neck squamous cell carcinomas.
Sci Transl Med
; 10(447)2018 06 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-29950445
18.
Down-regulation of AR splice variants through XPO1 suppression contributes to the inhibition of prostate cancer progression.
Oncotarget
; 9(82): 35327-35342, 2018 Oct 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-30450161
19.
Selective Inhibitors of Nuclear Export (SINE) compounds block proliferation and migration of triple negative breast cancer cells by restoring expression of ARRDC3.
Oncotarget
; 8(32): 52935-52947, 2017 Aug 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-28881784
20.
Clinical Dosing Regimen of Selinexor Maintains Normal Immune Homeostasis and T-cell Effector Function in Mice: Implications for Combination with Immunotherapy.
Mol Cancer Ther
; 16(3): 428-439, 2017 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-28148714