Detalles de la búsqueda
1.
Oncogenic mutations Q61L and Q61H confer active form-like structural features to the inactive state (state 1) conformation of H-Ras protein.
Biochem Biophys Res Commun
; 565: 85-90, 2021 08 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-34102474
2.
Phosphatidic acid-dependent localization and basal de-phosphorylation of RA-GEFs regulate lymphocyte trafficking.
BMC Biol
; 18(1): 75, 2020 06 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-32600317
3.
Phosphatidic acid regulates subcellular distribution of RA-GEFs critical for chemokine-dependent migration.
Biochem Biophys Res Commun
; 524(2): 325-331, 2020 04 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-31996307
4.
Phospholipase Cε plays a crucial role in neutrophilic inflammation accompanying acute lung injury through augmentation of CXC chemokine production from alveolar epithelial cells.
Respir Res
; 20(1): 9, 2019 Jan 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30634975
5.
Molecular Basis for Allosteric Inhibition of GTP-Bound H-Ras Protein by a Small-Molecule Compound Carrying a Naphthalene Ring.
Biochemistry
; 57(36): 5350-5358, 2018 09 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30141910
6.
Phospholipase Cϵ Activates Nuclear Factor-κB Signaling by Causing Cytoplasmic Localization of Ribosomal S6 Kinase and Facilitating Its Phosphorylation of Inhibitor κB in Colon Epithelial Cells.
J Biol Chem
; 291(24): 12586-12600, 2016 Jun 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-27053111
7.
Rapgef2, a guanine nucleotide exchange factor for Rap1 small GTPases, plays a crucial role in adherence junction (AJ) formation in radial glial cells through ERK-mediated upregulation of the AJ-constituent protein expression.
Biochem Biophys Res Commun
; 493(1): 139-145, 2017 11 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-28917843
8.
In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction.
Proc Natl Acad Sci U S A
; 110(20): 8182-7, 2013 May 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-23630290
9.
Critical function of RA-GEF-2/Rapgef6, a guanine nucleotide exchange factor for Rap1, in mouse spermatogenesis.
Biochem Biophys Res Commun
; 445(1): 89-94, 2014 Feb 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-24491570
10.
Solution structure of the state 1 conformer of GTP-bound H-Ras protein and distinct dynamic properties between the state 1 and state 2 conformers.
J Biol Chem
; 286(45): 39644-53, 2011 Nov 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-21930707
11.
Critical roles of interactions among switch I-preceding residues and between switch II and its neighboring alpha-helix in conformational dynamics of the GTP-bound Ras family small GTPases.
J Biol Chem
; 286(17): 15403-12, 2011 Apr 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-21388959
12.
Overexpression of phospholipase Cε in keratinocytes upregulates cytokine expression and causes dermatitis with acanthosis and T-cell infiltration.
Eur J Immunol
; 41(1): 202-13, 2011 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-21182091
13.
Crucial role of phospholipase Cepsilon in induction of local skin inflammatory reactions in the elicitation stage of allergic contact hypersensitivity.
J Immunol
; 184(2): 993-1002, 2010 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20007527
14.
Structural basis for conformational dynamics of GTP-bound Ras protein.
J Biol Chem
; 285(29): 22696-705, 2010 Jul 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-20479006
15.
Phospholipase CÉ has a crucial role in ultraviolet B-induced neutrophil-associated skin inflammation by regulating the expression of CXCL1/KC.
Lab Invest
; 91(5): 711-8, 2011 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-21321537
16.
PLCε cooperates with the NF-κB pathway to augment TNFα-stimulated CCL2/MCP1 expression in human keratinocyte.
Biochem Biophys Res Commun
; 414(1): 106-11, 2011 Oct 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-21951843
17.
Crucial role of the small GTPase Rac1 in insulin-stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma.
FASEB J
; 24(7): 2254-61, 2010 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-20203090
18.
Enhancement of ultraviolet B-induced skin tumor development in phospholipase Cε-knockout mice is associated with decreased cell death.
Carcinogenesis
; 31(10): 1897-902, 2010 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-20688835
19.
The M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis factor-alpha dependent regulation of integrin activation in splenocytes.
Mol Biol Cell
; 18(8): 2949-59, 2007 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-17538012
20.
Phospholipase Cepsilon promotes intestinal tumorigenesis of Apc(Min/+) mice through augmentation of inflammation and angiogenesis.
Carcinogenesis
; 30(8): 1424-32, 2009 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-19458037