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1.
Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist.
Proc Natl Acad Sci U S A
; 117(47): 29959-29967, 2020 11 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-33177239
2.
Evidence of an intestinal phosphate transporter alternative to type IIb sodium-dependent phosphate transporter in rats with chronic kidney disease.
Nephrol Dial Transplant
; 36(1): 68-75, 2021 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32879980
3.
Cynomolgus monkey model of interleukin-31-induced scratching depicts blockade of human interleukin-31 receptor A by a humanized monoclonal antibody.
Exp Dermatol
; 27(1): 14-21, 2018 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27714851
4.
Stronger Uricosuric Effects of the Novel Selective URAT1 Inhibitor UR-1102 Lowered Plasma Urate in Tufted Capuchin Monkeys to a Greater Extent than Benzbromarone.
J Pharmacol Exp Ther
; 357(1): 157-66, 2016 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-26907620
5.
Anti-factor IXa/X bispecific antibody ACE910 prevents joint bleeds in a long-term primate model of acquired hemophilia A.
Blood
; 124(20): 3165-71, 2014 Nov 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-25274508
6.
Competitive inhibition of SGLT2 by tofogliflozin or phlorizin induces urinary glucose excretion through extending splay in cynomolgus monkeys.
Am J Physiol Renal Physiol
; 306(12): F1520-33, 2014 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24761001
7.
A bispecific antibody NXT007 exerts a hemostatic activity in hemophilia A monkeys enough to keep a nonhemophilic state.
J Thromb Haemost
; 22(2): 430-440, 2024 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-37940048
8.
Selective SGLT2 inhibition by tofogliflozin reduces renal glucose reabsorption under hyperglycemic but not under hypo- or euglycemic conditions in rats.
Am J Physiol Endocrinol Metab
; 304(4): E414-23, 2013 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23249697
9.
Tofogliflozin, a potent and highly specific sodium/glucose cotransporter 2 inhibitor, improves glycemic control in diabetic rats and mice.
J Pharmacol Exp Ther
; 341(3): 692-701, 2012 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-22410641
10.
Novel myostatin-specific antibody enhances muscle strength in muscle disease models.
Sci Rep
; 11(1): 2160, 2021 01 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-33495503
11.
Antibody to CD137 Activated by Extracellular Adenosine Triphosphate Is Tumor Selective and Broadly Effective In Vivo without Systemic Immune Activation.
Cancer Discov
; 11(1): 158-175, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32847940
12.
Optimization of PTH/PTHrP Hybrid Peptides to Derive a Long-Acting PTH Analog (LA-PTH).
JBMR Plus
; 4(7): e10367, 2020 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-32666018
13.
Mitemcinal (GM-611), an orally active motilin receptor agonist, improves delayed gastric emptying in a canine model of diabetic gastroparesis.
Clin Exp Pharmacol Physiol
; 35(7): 788-96, 2008 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-18346169
14.
Inhibin ßE (INHBE) is a possible insulin resistance-associated hepatokine identified by comprehensive gene expression analysis in human liver biopsy samples.
PLoS One
; 13(3): e0194798, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29596463
15.
Emicizumab, A Bispecific Antibody to Factors IX/IXa and X/Xa, Does Not Interfere with Antithrombin or TFPI Activity In Vitro.
TH Open
; 2(1): e96-e103, 2018 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-31249933
16.
Antibody engineering to generate SKY59, a long-acting anti-C5 recycling antibody.
PLoS One
; 13(12): e0209509, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-30592762
17.
Factor VIIIa-mimetic cofactor activity of a bispecific antibody to factors IX/IXa and X/Xa, emicizumab, depends on its ability to bridge the antigens.
Thromb Haemost
; 117(7): 1348-1357, 2017 06 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-28451690
18.
Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases.
Sci Rep
; 7(1): 1080, 2017 04 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-28439081
19.
An anti-glypican 3/CD3 bispecific T cell-redirecting antibody for treatment of solid tumors.
Sci Transl Med
; 9(410)2017 Oct 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-28978751
20.
Pharmacodynamic Actions of a Long-Acting PTH Analog (LA-PTH) in Thyroparathyroidectomized (TPTX) Rats and Normal Monkeys.
J Bone Miner Res
; 31(7): 1405-12, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-26865415