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1.
Discovery of Novel and Potent Stearoyl Coenzyme A Desaturase 1 (SCD1) Inhibitors as Anticancer Agents.
Bioorg Med Chem
; 25(14): 3768-3779, 2017 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28571972
2.
Design and synthesis of novel pyrimido[4,5-b]azepine derivatives as HER2/EGFR dual inhibitors.
Bioorg Med Chem
; 21(8): 2250-2261, 2013 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23490150
3.
Design and synthesis of pyrrolo[3,2-d]pyrimidine HER2/EGFR dual inhibitors: improvement of the physicochemical and pharmacokinetic profiles for potent in vivo anti-tumor efficacy.
Bioorg Med Chem
; 20(20): 6171-80, 2012 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22980219
4.
Discovery of Potent, Selective, and Brain-Penetrant 1 H-Pyrazol-5-yl-1 H-pyrrolo[2,3- b]pyridines as Anaplastic Lymphoma Kinase (ALK) Inhibitors.
J Med Chem
; 62(10): 4915-4935, 2019 05 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-31009559
5.
Antitumor Activity of TAK-285, an Investigational, Non-Pgp Substrate HER2/EGFR Kinase Inhibitor, in Cultured Tumor Cells, Mouse and Rat Xenograft Tumors, and in an HER2-Positive Brain Metastasis Model.
J Cancer
; 4(7): 557-65, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-23983820
6.
Structure-Based Approach for the Discovery of Pyrrolo[3,2-d]pyrimidine-Based EGFR T790M/L858R Mutant Inhibitors.
ACS Med Chem Lett
; 4(2): 201-5, 2013 Feb 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900643
7.
Design and synthesis of pyrrolo[3,2-d]pyrimidine human epidermal growth factor receptor 2 (HER2)/epidermal growth factor receptor (EGFR) dual inhibitors: exploration of novel back-pocket binders.
J Med Chem
; 55(8): 3975-91, 2012 Apr 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-22439974
8.
Design and synthesis of novel human epidermal growth factor receptor 2 (HER2)/epidermal growth factor receptor (EGFR) dual inhibitors bearing a pyrrolo[3,2-d]pyrimidine scaffold.
J Med Chem
; 54(23): 8030-50, 2011 Dec 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-22003817
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