Detalles de la búsqueda
1.
Characterization of Pharmacokinetics, Biotransformation and Elimination of Pomotrelvir Orally Administered in Healthy Male Adults Using Two [14C]-Labeled Microtracers with Separate Labeling Positions.
Drug Metab Dispos
; 51(12): 1607-1614, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37684056
2.
Exposure-response relationships for the efficacy and safety of filgotinib and its metabolite GS-829845 in subjects with rheumatoid arthritis based on phase 2 and phase 3 studies.
Br J Clin Pharmacol
; 88(7): 3211-3221, 2022 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35072287
3.
An LC-MS/MS method for determination of tenofovir (TFV) in human plasma following tenofovir alafenamide (TAF) administration: Development, validation, cross-validation, and use of formic acid as plasma TFV stabilizer.
Anal Biochem
; 593: 113611, 2020 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32035040
4.
Preclinical Pharmacokinetics and First-in-Human Pharmacokinetics, Safety, and Tolerability of Velpatasvir, a Pangenotypic Hepatitis C Virus NS5A Inhibitor, in Healthy Subjects.
Antimicrob Agents Chemother
; 61(5)2017 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28193657
5.
Pharmacokinetics and Safety of Tenofovir Alafenamide in HIV-Uninfected Subjects with Severe Renal Impairment.
Antimicrob Agents Chemother
; 60(9): 5135-40, 2016 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27216057
6.
Pharmacokinetics and safety of boosted elvitegravir in subjects with hepatic impairment.
Antimicrob Agents Chemother
; 58(5): 2564-9, 2014 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-24550332
7.
Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate versus ritonavir-boosted atazanavir plus co-formulated emtricitabine and tenofovir disoproxil fumarate for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3, non-inferiority trial.
Lancet
; 379(9835): 2429-2438, 2012 Jun 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-22748590
8.
Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus co-formulated efavirenz, emtricitabine, and tenofovir for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3 trial, analysis of results after 48 weeks.
Lancet
; 379(9835): 2439-2448, 2012 Jun 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-22748591
9.
A comprehensive evaluation in clinic and physiologically-based pharmacokinetic modeling and simulation to confirm lack of cytochrome P450-mediated drug-drug interaction potential for pomotrelvir.
CPT Pharmacometrics Syst Pharmacol
; 12(10): 1553-1564, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37614073
10.
Activity of elvitegravir, a once-daily integrase inhibitor, against resistant HIV Type 1: results of a phase 2, randomized, controlled, dose-ranging clinical trial.
J Infect Dis
; 201(6): 814-22, 2010 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20146631
11.
Lack of Drug-Drug Interaction Between Filgotinib, a Selective JAK1 Inhibitor, and Oral Hormonal Contraceptives Levonorgestrel/Ethinyl Estradiol in Healthy Volunteers.
Clin Pharmacol Drug Dev
; 10(4): 376-383, 2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32989920
12.
Organic Anion Transporting Polypeptide Inhibition Dramatically Increases Plasma Exposure but not Pharmacodynamic Effect nor Inferred Hepatic Intracellular Exposure of Firsocostat.
Clin Pharmacol Ther
; 109(5): 1334-1341, 2021 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33141923
13.
Filgotinib, a JAK1 Inhibitor, Has No Effect on QT Interval in Healthy Subjects.
Clin Pharmacol Drug Dev
; 9(1): 32-40, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31797578
14.
Confirmation of the drug-drug interaction potential between cobicistat-boosted antiretroviral regimens and hormonal contraceptives.
Antivir Ther
; 24(8): 557-566, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31933482
15.
Chronic administration of tenofovir to rhesus macaques from infancy through adulthood and pregnancy: summary of pharmacokinetics and biological and virological effects.
Antimicrob Agents Chemother
; 52(9): 3144-60, 2008 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-18573931
16.
Pharmacokinetics of elvitegravir and etravirine following coadministration of ritonavir-boosted elvitegravir and etravirine.
Antivir Ther
; 13(8): 1011-7, 2008.
Artículo
en Inglés
| MEDLINE | ID: mdl-19195326
17.
Drug-Drug Interaction Profile of the Fixed-Dose Combination Tablet Regimen Ledipasvir/Sofosbuvir.
Clin Pharmacokinet
; 57(11): 1369-1383, 2018 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-29644537
18.
A Thorough QT Study to Evaluate the Effects of Supratherapeutic Doses of Ledipasvir on the QTc Interval in Healthy Subjects.
Clin Pharmacol Drug Dev
; 7(6): 641-651, 2018 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29058821
19.
Pharmacokinetics of Tenofovir Alafenamide When Coadministered With Other HIV Antiretrovirals.
J Acquir Immune Defic Syndr
; 78(4): 465-472, 2018 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29649076
20.
Cytochrome P450 3A Induction Predicts P-glycoprotein Induction; Part 1: Establishing Induction Relationships Using Ascending Dose Rifampin.
Clin Pharmacol Ther
; 104(6): 1182-1190, 2018 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29569723