Detalles de la búsqueda
1.
A genetic basis for friendship? Homophily for membrane-associated PDE11A-cAMP-CREB signaling in CA1 of hippocampus dictates mutual social preference in male and female mice.
Mol Psychiatry
; 26(12): 7107-7117, 2021 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34321593
2.
Aging triggers an upregulation of a multitude of cytokines in the male and especially the female rodent hippocampus but more discrete changes in other brain regions.
J Neuroinflammation
; 18(1): 219, 2021 Sep 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-34551810
3.
A homozygous loss-of-function mutation in PDE2A associated to early-onset hereditary chorea.
Mov Disord
; 33(3): 482-488, 2018 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29392776
4.
Biologic that disrupts PDE11A4 homodimerization in hippocampus CA1 reverses age-related cognitive decline of social memories in mice.
Neurobiol Aging
; 131: 39-51, 2023 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-37572526
5.
First Optimization of Novel, Potent, Selective PDE11A4 Inhibitors for Age-Related Cognitive Decline.
J Med Chem
; 66(21): 14597-14608, 2023 11 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37862143
6.
The sleep quality- and myopia-linked PDE11A-Y727C variant impacts neural physiology by reducing catalytic activity and altering subcellular compartmentalization of the enzyme.
bioRxiv
; 2023 Nov 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-38014312
7.
The Sleep Quality- and Myopia-Linked PDE11A-Y727C Variant Impacts Neural Physiology by Reducing Catalytic Activity and Altering Subcellular Compartmentalization of the Enzyme.
Cells
; 12(24)2023 12 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-38132157
8.
Conserved age-related increases in hippocampal PDE11A4 cause unexpected proteinopathies and cognitive decline of social associative memories.
Aging Cell
; 21(10): e13687, 2022 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36073342
9.
Alterations in cyclic nucleotide signaling are implicated in healthy aging and age-related pathologies of the brain.
Vitam Horm
; 115: 265-316, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-33706951
10.
The Role of PDE11A4 in Social Isolation-Induced Changes in Intracellular Signaling and Neuroinflammation.
Front Pharmacol
; 12: 749628, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34887755
11.
Genetic manipulation of cyclic nucleotide signaling during hippocampal neuroplasticity and memory formation.
Prog Neurobiol
; 190: 101799, 2020 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32360536
12.
Phosphodiesterases PDE2A and PDE10A both change mRNA expression in the human brain with age, but only PDE2A changes in a region-specific manner with psychiatric disease.
Cell Signal
; 70: 109592, 2020 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-32119913
13.
Therapeutic targeting of 3',5'-cyclic nucleotide phosphodiesterases: inhibition and beyond.
Nat Rev Drug Discov
; 18(10): 770-796, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31388135
14.
Loss of Function of Phosphodiesterase 11A4 Shows that Recent and Remote Long-Term Memories Can Be Uncoupled.
Curr Biol
; 29(14): 2307-2321.e5, 2019 07 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-31303492
15.
Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain.
Cell Signal
; 42: 281-291, 2018 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-29175000
16.
Identification of new PDE9A isoforms and how their expression and subcellular compartmentalization in the brain change across the life span.
Neurobiol Aging
; 65: 217-234, 2018 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29505961
17.
A Role for Phosphodiesterase 11A (PDE11A) in the Formation of Social Memories and the Stabilization of Mood.
Adv Neurobiol
; 17: 201-230, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28956334
18.
PDE11A regulates social behaviors and is a key mechanism by which social experience sculpts the brain.
Neuroscience
; 335: 151-69, 2016 Oct 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-27544407
19.
Phosphodiesterase 11A (PDE11A), Enriched in Ventral Hippocampus Neurons, is Required for Consolidation of Social but not Nonsocial Memories in Mice.
Neuropsychopharmacology
; 41(12): 2920-2931, 2016 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-27339393
20.
Does phosphodiesterase 11A (PDE11A) hold promise as a future therapeutic target?
Curr Pharm Des
; 21(3): 389-416, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25159071