Detalles de la búsqueda
1.
Biosynthesis of a new skyllamycin in Streptomyces nodosus: a cytochrome P450 forms an epoxide in the cinnamoyl chain.
Org Biomol Chem
; 22(14): 2835-2843, 2024 04 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-38511621
2.
Structural analysis of P450 AmphL from Streptomyces nodosus provides insights into substrate selectivity of polyene macrolide antibiotic biosynthetic P450s.
J Biol Chem
; 298(4): 101746, 2022 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-35189143
3.
Concerning P450 Evolution: Structural Analyses Support Bacterial Origin of Sterol 14α-Demethylases.
Mol Biol Evol
; 38(3): 952-967, 2021 03 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-33031537
4.
Glow flow ionization mass spectrometry of small molecules. A comparison of a glow flow ionization source ('GlowFlow') with electrospray ionization and atmospheric pressure chemical ionization.
Rapid Commun Mass Spectrom
; 36(15): e9327, 2022 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35610187
5.
On the occurrence of cytochrome P450 in viruses.
Proc Natl Acad Sci U S A
; 116(25): 12343-12352, 2019 06 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-31167942
6.
Species-Specific Differences in C-5 Sterol Desaturase Function Influence the Outcome of Azole Antifungal Exposure.
Antimicrob Agents Chemother
; 65(12): e0104421, 2021 11 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-34516249
7.
ERG6 and ERG2 Are Major Targets Conferring Reduced Susceptibility to Amphotericin B in Clinical Candida glabrata Isolates in Kuwait.
Antimicrob Agents Chemother
; 63(2)2019 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30455247
8.
In Vitro Activities of the Novel Investigational Tetrazoles VT-1161 and VT-1598 Compared to the Triazole Antifungals against Azole-Resistant Strains and Clinical Isolates of Candida albicans.
Antimicrob Agents Chemother
; 63(6)2019 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-30910896
9.
The Evolution of Azole Resistance in Candida albicans Sterol 14α-Demethylase (CYP51) through Incremental Amino Acid Substitutions.
Antimicrob Agents Chemother
; 63(5)2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30783005
10.
In Vitro and In Vivo Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection.
Antimicrob Agents Chemother
; 62(5)2018 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29439966
11.
The Tetrazole VT-1161 Is a Potent Inhibitor of Trichophyton rubrum through Its Inhibition of T. rubrum CYP51.
Antimicrob Agents Chemother
; 61(7)2017 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-28483956
12.
In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection.
Antimicrob Agents Chemother
; 61(5)2017 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28223388
13.
Loss of C-5 Sterol Desaturase Activity Results in Increased Resistance to Azole and Echinocandin Antifungals in a Clinical Isolate of Candida parapsilosis.
Antimicrob Agents Chemother
; 61(9)2017 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28630186
14.
The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme.
Antimicrob Agents Chemother
; 60(8): 4530-8, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27161631
15.
Paralog re-emergence: a novel, historically contingent mechanism in the evolution of antimicrobial resistance.
Mol Biol Evol
; 31(7): 1793-802, 2014 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-24732957
16.
In Vitro Biochemical Study of CYP51-Mediated Azole Resistance in Aspergillus fumigatus.
Antimicrob Agents Chemother
; 59(12): 7771-8, 2015 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26459890
17.
Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51).
Antimicrob Agents Chemother
; 59(8): 4707-13, 2015 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-26014948
18.
Novel Substrate Specificity and Temperature-Sensitive Activity of Mycosphaerella graminicola CYP51 Supported by the Native NADPH Cytochrome P450 Reductase.
Appl Environ Microbiol
; 81(10): 3379-86, 2015 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25746994
19.
Clotrimazole as a potent agent for treating the oomycete fish pathogen Saprolegnia parasitica through inhibition of sterol 14α-demethylase (CYP51).
Appl Environ Microbiol
; 80(19): 6154-66, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-25085484
20.
Identification of Potent and Selective Inhibitors of Acanthamoeba: Structural Insights into Sterol 14α-Demethylase as a Key Drug Target.
J Med Chem
; 67(9): 7443-7457, 2024 May 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-38683753